Generic Name: Metronidazole
Product Name: Metrogyl
Metronidazole is used to treat the following types of infections:
- Certain types of bacterial infections
- Protozoal infections
- Pseudomembranous colitis
- Dental infections, including acute gingivitis
- Intra-abdominal infections
- Aspiration pneumonia
- Lung abscess
- Bacterial vaginosis
- Pelvic inflammatory disease
- Eradications of helicobacter pylori bacteria, which is responsible for causing peptic ulcer disease
- Prevention of infections during and following surgery.
Metronidazole is thought to act by interfering with DNA synthesis in bacteria.
Oral dosing: 200-400 mg every 8-12 hours up to a maximum dose of 4 g daily.
Rectal dosing: 1 g every 8-12 hours.
5 mg/kg every 8 hours given orally or intravenously.
Children aged 1-5 years: 250 mg 3 times a day.
Children aged 6-12 years: 500 mg three times day.
For severe infections:
500 mg intravenously every 8-12 hours to a maximum dose of 4mg a day.
Adults: 400 mg orally three every 8 hours for 7-10 days.
Children: 10 mg/kg orally every 8 hours for 7-10 days.
Intravenous infusion: 500 mg with the infusion ending at the time of induction.
Rectal dosing: 1 g given as a single dose 8 hours prior to surgery.
Oral dosing: 400 mg given as a single dose 1-2 hours prior to surgery.
12.5 mg/kg given intravenously to a maximum dose of 500 mg. The infusion should end at the time of induction
Acute intestinal amoebiasis:
Adults: 600-800 mg orally every 8 hours for 6-10 days.
Children: 15 mg/kg orally every 8 hours to a maximum dose of 800 mg every 8 hours given for 6-10 days.
The treatment course can be repeated after 2 weeks if necessary.
Adults: 600-800 mg orally every 8 hours for 10-14 days.
Children: 15 mg/kg orally every 8 hours to a maximum dose of 800 mg every 8 hours given for 10-14 days.
400 mg orally twice a day for 5 days.
2 g orally given as a single dose. If this fails 400 mg should be given twice daily for 5 days.
In women who are pregnant or lactating the 5-day course should be used.
Sexual partners also need to be treated.
Adults: 2 g orally for 3 days. If this fails, 400 mg should be given every 8 hours for 7 days.
Children: 30 mg/kg up to a maximum of 2g given orally once a day for 3 days or, if this fails, 10 mg/kg should be given 3 times a day for 7 days.
Common side effects
- Metallic taste
- Inflammation and clotting of veins if given intravenously.
Uncommon side effects
- Allergic reactions including rash, itch, flushing and fever
- Inflammation of the tongue
- Sores around and in the mouth
- Dark coloured urine
- Loss of sensation.
For further information talk to your doctor.