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Amoxil Parenteral Preparations

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Generic Name: amoxycillin sodium
Product Name: Amoxil Parenteral Preparations (injection)

Indication: What Amoxil Parenteral is used for

Amoxycillin belongs to the penicillin group of antibiotics. Amoxil is used to treat a range of infections caused by bacteria. These may be infections of the blood (septicaemia), chest (pneumonia), urinary and genital tract, skin and fleshy tissues.

Your doctor may have prescribed Amoxil for another reason.

There is no evidence that Amoxil Parenteral is addictive.

Action: How Amoxil Parenteral works

Amoxil contains a penicillin called amoxycillin as the active ingredient.

Amoxycillin works by killing the bacteria that cause these infections. Amoxil can also be used to prevent infection.

Amoxicillin is similar to ampicillin in its bactericidal action against Gram-positive and Gram-negative susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of the cell wall mucopeptide.

Amoxicillin is active in vitro against most strains of Haemophilus influenzae*, Neisseria gonorrhoeae*, Neisseria meningitidis, Escherichia coli*, Proteus mirabilis* and Salmonellae.

*Activity refers only to betalactamase negative strains.

Because amoxicillin does not resist destruction by penicillinase, it is not active against penicillinase-producing organisms, particularly penicillinase-producing staphylococci. All strains of Pseudomonas species, Klebsiella species, Enterobacter species, indole-positive Proteus species, Serratia marcescens, Citrobacter species, penicillinase-producing N. gonorrhoeae and penicillinase-producing H. influenzae are resistant.

In vitro studies have demonstrated the susceptibility of most strains of the following gram-positive bacteria: alpha- and beta-haemolytic streptococci, Diplococcus pneumoniae, non-penicillinase producing staphylococci and Streptococcus faecalis. These organisms are susceptible to amoxicillin at serum concentrations, which may be expected following the recommended doses. However, some of the organisms were susceptible to amoxicillin only at concentrations achieved in the urine.

Escherichia coli isolates are becoming increasingly resistant to amoxicillin in vitro due to the
presence of penicillinase-producing strains.

Strains of gonococci which are relatively resistant to benzylpenicillin may be sensitive to
amoxicillin.

Amoxil injections contain the active ingredient amoxycillin. There are no inactive ingredients in Amoxil injections.

Amoxil does not contain lactose, sucrose or any azo dyes.

Dose advice: How to use Amoxil Parenteral

Before you are given Amoxil Parenteral

Amoxil must not be used if

  • You are allergic to amoxycillin, other penicillins or similar types of antibiotics such as cephalosporins. If you have ever had an allergic reaction (such as a rash) when taking an antibiotic you should tell your doctor before you take Amoxil;
  • The expiry date (EXP) printed on the pack has passed;
  • The packaging is torn or shows signs of tampering.

Tell your doctor if

You must tell your doctor if:

  • You are allergic to foods, dyes, preservatives or any other medicines;
  • You have ever had an allergic reaction (such as a rash) to any antibiotics in the past;
  • You have glandular fever (mononucleosis);
  • You are pregnant or think you may be pregnant or are breastfeeding. Amoxil may be used during pregnancy (Australian Use in Pregnancy Category A). Amoxil can pass to your baby from breast milk;
  • You have liver or kidney problems. The dosage of Amoxil may need to be changed or you may need to be given an alternative medicine;
  • You are taking any other medicines, including medicines you buy without a prescription. In particular tell the doctor if you are taking any of the following:
    • Medicines used to treat gout e.g. probenecid or allopurinol;
    • The contraceptive pill. As with other antibiotics, you may need to use extra birth control methods e.g. condoms;
    • Other antibiotics;
    • Anticoagulants (used to prevent blood clots) such as warfarin;
    • These may interfere with the actions of Amoxil.

Some medicines may affect the way other medicines work. Your doctor or pharmacist will be able to tell you which medicines are safe to take with Amoxil.

If you have not told your doctor about any of these things, tell them before you receive any Amoxil.

How Amoxil is given

How much to give

Amoxil will be administered as directed under the supervision of a doctor or nurse. You will not be expected to give yourself this medication.

How Amoxil is given

Your doctor or nurse will inject the necessary dose of Amoxil. It may be given by injection into the muscle of the upper arm or buttock or into a vein. Your doctor will decide the best method of giving the injection to you.

The usual dose of Amoxil is one injection every six or eight hours.

How long to give Amoxil for

Amoxil should be administered for as long as recommended by your doctor. The length of treatment will be decided by your doctor.

Do not stop taking Amoxil, or change the dose without first checking with your doctor.

If you are given too much Amoxil (overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone 131126) for advice, if you think you or anyone else may have been given too much Amoxil, even if there are no signs of discomfort or poisoning.

If you are not sure what to do, contact your doctor, pharmacist or nearest hospital.

While you are being given Amoxil

Things you must do

If you develop itching, swelling or a skin rash when you are receiving Amoxil, tell the doctor or nurse immediately.

If you develop severe diarrhoea when receiving Amoxil tell the doctor or nurse as soon as possible. Do not take any medication to stop the diarrhoea (e.g. Lomotil or Imodium).

Things you must not do

Do not give this medicine to anyone else, even if their symptoms seem similar to yours.

Do not use Amoxil to treat any other complaints unless your doctor says to.

Things to be careful of

Be careful driving or operating machinery until you know how Amoxil affects you.

Storage

Keep this medicine where children cannot reach it, such as in a locked cupboard.

Keep the pack in a cool dry place where the temperature stays below 25°C.

Do not leave it in the car on a hot day. Do not store medicine in the bathroom or near a sink. Heat and dampness can destroy some medicines.

Ask your pharmacist what to do with any unused injections.

Schedule of Amoxil Parenteral

Amoxil Parenteral is a Schedule 4 (prescription only) medicine.

Side effects of Amoxil Parenteral

Check with your doctor as soon as possible if you think you are experiencing any side effects or allergic reactions due to taking Amoxil, even if the problem is not listed below. Like other medicines, Amoxil can cause some side effects. If they occur, they are most likely to be minor and temporary. However, some may be serious and need medical attention.

Mild effects

Tell your doctor or nurse if you notice any of the following that are troublesome or ongoing:

  • Diarrhoea (several loose bowel movements per day), indigestion, feeling sick or being sick;
  • Soreness of the mouth or tongue;
  • Overgrowth of yeast infections (thrush).

More serious effects

Tell your doctor or nurse immediately if you notice any of the following:

  • Wheezing, swelling of the lips/mouth, difficulty in breathing, hayfever, lumpy rash (hives) or fainting. These could be symptoms of an allergic reaction;
  • Pain around the site of injection;
  • Unusual bleeding or bruising;
  • Yellowing of the skin or eyes;
  • Dark urine or pale stools;
  • Difficulty or pain on passing urine;
  • Severe diarrhoea.

Remember you should tell your doctor, nurse or pharmacist as soon as possible if any of these, or any other unusual events or problems occur during or after treatment with Amoxil.

This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects not yet known. Tell your doctor or pharmacist if you notice any side effects from your medicine which are not mentioned here.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

For further information talk to your doctor.

References

  1. Amoxil Parenteral Consumer Medicine Information (CMI). St Leonards, NSW: Aspen Pharma Pty Ltd. July 2009. [PDF]
  2. Amoxil Parenteral Product Information (PI). St Leonards, NSW: Aspen Pharma Pty Ltd. October 2017. [PDF]
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Dates

Posted On: 22 July, 2003
Modified On: 26 September, 2018
Reviewed On: 26 September, 2018

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Created by: myVMC