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Generic Name: Sibutramine hydrochloride
Product Name: Reductil


Reductil is a medication used to help individuals who are obese – i.e. with a body mass index (BMI) ≥ 30 – to lose weight. Before a doctor will prescribe Reductil to you, you must have previously tried to lose weight by modifying your diet and increasing the amount of physical activity you do.

People who are overweight (BMI > 27) might also be prescribed Reductil if they have a high risk of becoming obese. Factors which increase an overweight individual’s risk of obesity include:

Weight loss
For more information on obesity, health and social issues, and methods of weight loss, as well as some useful tools, see
Obesity and Weight Loss.



Reductil contains the active ingredient sibutramine, which works by increasing the level of two chemicals found in the brain (serotonin and noradrenalin) which regulate appetite. These chemicals send signals which tell a person that they are becoming hungry and need to eat, or that they are becoming full and need to stop eating. Sibutramine causes an increase in the chemicals which cause a feeling of fullness or satiety (i.e. it suppresses the appetite), and can therefore help reduce the amount a person eats.

Reductil can also increase the rate of an individual’s resting metabolism, or the amount of energy they consume when they are resting. During weight loss, it is common for the resting metabolic rate (RMR) to decrease as the amount of food consumed is decreased. This means that the rate at which the body burns up food is slowed down, which has negative effects on weight loss. Taking Reductil can stop this from happening.

Dose advice

Dose information

A doctor will usually prescribe one 10 mg tablet of Reductil each day, which can be taken with or without food. The doctor will also prescribe a calorie- and fat-controlled diet and exercise. Reductil is not effective in reducing weight without also reducing calorie intake and increasing physical activity.

In special cases, where an individual fails to lose weight after eating a reduced-calorie diet, exercising and taking 10 mg of Reductil each day for 4–6 weeks, the doctor may increase the dose to 15 mg per day.

Reductil is typically used for at least six months and up to two years.

If you have any questions about the correct way to take Reductil, please speak to your doctor.


Reductil should not be used under certain circumstances. Tell your doctor if you have:


Special care needs to be taken when using Reductil under certain circumstances. Tell your doctor if you have:

As a further precaution, the doctor is likely to monitor the blood pressure (BP) and heart rate (HR) of all individuals taking Reductil, as it has been shown to increase BP and HR in some cases. Monitoring will typically occur every two weeks for the first three months of treatment and at least every three months thereafter. The doctor may discontinue treatment with Reductil if the BP or HR increases.


Reductil is a Pregnancy Category C medication. It is not prescribed for use in pregnancy as its safety has not been established. Weight loss using appetite suppressants is not recommended during pregnancy.


The safety of using Reductil during breastfeeding has not been established.


Sibutramine is a Schedule 4 medication.1

Common side effects

All medicines have side effects. Most commonly the side effects are minor; however, some can be more serious. Usually the benefits of taking a medication outweigh the associated side effects. Your doctor would have considered these side effects before starting you on Reductil.

Very common side effects are those that occur in more than 10% of people given Reductil. These include:

Common side effects are those that occur in more than 10% of people given Reductil. These include:

If you experience any of the listed side effects, or any other symptoms that appear abnormal or unusual, please tell your doctor.


  1. Reductil [online]. St Leonards, NSW: MIMS Online; 20 June 2008 [cited 5 September 2009]. Available from: URL link
  2. Sibutramine [online]. Adelaide, SA: Australian Medicines Handbook; July 2009 [cited 5 September 2009]. Available from: URL link

Diseases/conditions treated by Reductil:


Treatments associated with Reductil:

For further information talk to your doctor.

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Posted On: 24 August, 2007
Modified On: 21 January, 2011
Reviewed On: 19 January, 2011

Created by: myVMC