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Generic Name: Fluoxetine hydrochloride
Product Name: Fluohexal



SSRIs work by selective inhibition of pre-synaptic uptake of serotonin (5- hydroxytryptamine, 5-HT). Fluoxetine has an active metabolite norfluoxetine, that contributes significantly to its effects and has a long half life (up to 16 days). Fluoxetine inhibits CYP2D6 and its active metabolite, norfluoxetine, inhibits CYP3A4. This contributes to specific drug interactions.

Dose advice

Major depression:

  • 20mg once daily, gradually increasing if necessary to 60mg daily.
  • Use of maintenance doses > 20mg is not usually necessary.

Obsessive compulsive disorder, Bulimia nervosa:

  • 20mg once daily, gradually increasing as indicated to 60-80mg daily.

Panic disorder:

  • 10mg daily, do not exceed 20mg daily.

Post-traumatic stress disorder:

  • Continuous treatment: 20mg once daily; Cyclic treatment: 20mg once daily starting 14 days before the anticipated start of menstruation until the first full day of menses.



Common side effects

Uncommon side effects

  • Extrapyramidal reactions (including Tardive Dyskinesia and dystonia)
  • Sedation
  • Confusion
  • Palpitations
  • Tachycardia
  • Hypotension
  • Abnormal platelet aggregation/ haemorrhagic complications (e.g. bruising, epistaxis, purpura)


  • Elevated liver enzymes
  • Hepatitis
  • Hepatic failure
  • Galactorrhoea
  • Blood dyscrasias
  • Seizures
  • Akathesia

For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 1 January, 1970


Created by: myVMC