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Generic Name: moclobemide
Product Name: Aurorix

Indication: What Aurorix is used for

Aurorix belongs to a group of medicines called antidepressants. Antidepressants are used to treat depression and work on the central nervous system.

Your doctor, however, may have prescribed Aurorix for another purpose. Ask your doctor if you have any questions about why Aurorix has been prescribed for you.

This medicine is available only with a doctor’s prescription.

Do not give Aurorix to children or adolescents under 18 years of age. The safety and effectiveness of Aurorix in this age group have not been established.

Action: How Aurorix works

Aurorix contains the active ingredient called moclobemide. Moclobemide belongs to a group of medicines called reversible inhibitors of monoamine oxidase A.  The metabolism of dopamine, noradrenaline and serotonin is decreased by this effect, and this leads to increased extracellular concentrations of these neuronal transmitters. As a result of its elevating effect on mood and psychomotor activity, Aurorix relieves symptoms such as dysphoria, exhaustion, lack of drive and poor ability to concentrate.

Each Aurorix 150 mg tablet contains 150 mg of the active ingredient moclobemide.

Each Aurorix 300 mg tablet contains 300 mg of the active ingredient moclobemide.

Aurorix 150 mg and 300 mg tablets both contain the inactive ingredients lactose, starch-maize, povidone (1201), sodium starch glycollate, magnesium stearate (470), ethyl cellulose, macrogol 6000, hypromellose (464), purified talc (553), and are coloured with titanium dioxide (171).

Aurorix 150 mg tablets also contain yellow iron oxide (172).

Aurorix tablets are gluten free.

Dose advice: How to use Aurorix

Before you take Aurorix

Do not take Aurorix if

  • You have ever had an allergic reaction to Aurorix or any of the ingredients listed here;
  • You are suffering from severe confusion;
  • You are taking:
    • Clomipramine (Anafranil);
    • Selegiline (Eldepryl);
    • Bupropion (Zyban);
    • Triptans (a family of medicines commonly used to treat migraines e.g. Triptazig);
    • Pethidine;
    • Tramadol (Durotram, Zydol);
    • Dextromethorphan (often found in cough and cold medicines);
    • Linezolid (Zyvox).
  • You are taking other medications known as selective serotonin reuptake inhibitors or tricyclic antidepressants. Taking Aurorix with these medicines may cause a serious reaction called serotonin syndrome. This can cause a sudden increase in body temperature, high blood pressure, and convulsions.

Do not take Aurorix after the expiry date (EXP) printed on the pack. It may have no effect at all or, worse, an entirely unexpected effect if you take it after the expiry date.

Do not take Aurorix if the packaging is torn or shows signs of tampering or if the tablets appear damaged in some way. If it has expired or is damaged, return the product to your pharmacist for disposal.

If you are not sure if you should be taking Aurorix, talk to your doctor.

You must tell your doctor if

  • You are allergic to any other medicines, foods, dyes or preservatives;
  • You have any other health problems including:
    • Liver disease;
    • High blood pressure;
    • A personal history or family history of bipolar disorder;
    • Mental illness other than depression, including schizophrenia, agitation, and excitation;
    • Thyrotoxicosis (a condition of excessive thyroid hormones);
    • Phaeochromocytoma (a rare tumour of adrenal gland);
    • Rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose-galactose malabsorption;
  • You are pregnant or intend to become pregnant;
  • You are breastfeeding or wish to breastfeed.

Your doctor will discuss the risks and benefits of using Aurorix when pregnant and while breastfeeding.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you have bought from a pharmacy, supermarket or health food shop.

Some commonly used medicines that may interfere with Aurorix are:

  • Cimetidine;
  • Dextromethorphan (often found in cough and cold medicines);
  • Pethidine;
  • Selegiline;
  • Bupropion;
  • Triptans;
  • Tramadol;
  • Linezolid;
  • Proton pump inhibitors
  • Serotonin agonists (e.g. buspirone, sumatriptan);
  • John’s wort (Hypericum)- containing phytotherapeutic products;
  • Opiates e.g. morphine, fentanyl, and codeine;
  • Adrenergics;
  • Sibutramine.

Other antidepressant medicines may interfere with Aurorix such as fluoxetine, fluvoxamine, paroxetine, sertraline, amitriptyline and nortriptyline, trimipramine and maprotiline, venlafaxine, clomipramine, citalopram, and paroxetine.

Moclobemide may cause an additional drop in blood pressure if you are taking metoprolol.

Your doctor or pharmacist has a complete list of medicines to avoid while taking Aurorix. If you have not told your doctor about any of the above, tell them before you start taking Aurorix.

How to take Aurorix

Take Aurorix exactly as your doctor has prescribed.

How much to take

Your doctor will tell you how many Aurorix tablets to take each day.

The usual dose is between 300 mg and 600 mg per day. The tablets are taken twice daily after meals.

How to take it

Tablets should be swallowed whole with a glass of water after meals.

You should follow your doctor’s instructions carefully if changing from one antidepressant to another and report any unexpected effects if they occur.

When to take it

Aurorix should be taken morning and evening at the end of your meal.

How long to take Aurorix

For depression, the length of treatment will depend on how quickly your symptoms improve. Most antidepressants take time to work so don’t be discouraged if you don’t feel better right away. Some of your symptoms may improve in 1 or 2 weeks but, it can take up to 4 or 6 weeks to feel any real improvement. Even when you feel well, you will usually have to take Aurorix for several months or even longer to make sure the benefits will last. Continue taking it until your doctor tells you to stop.

If you forget to take Aurorix

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember then go back to taking it as soon as you would normally.

Do not double a dose to make up for the one you have missed.

In case of an overdose

Immediately telephone your doctor or the Poisons Information Centre on telephone 13 11 26 for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much Aurorix. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

Keep telephone numbers for these places handy.

Some signs and symptoms of overdose include nausea, vomiting, drowsiness, slurred speech, reduced reflexes, and agitation.

While you are taking Aurorix

Things you must do

Tell all doctors, dentists, and pharmacists who are treating you that you are taking Aurorix.

Do not take any other medicines whether they require a prescription or not without first telling your doctor.

Tell your doctor if you become pregnant while taking Aurorix.

Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily.

Tell your doctor if you feel the tablets are not helping your condition. If you are being treated for depression, tell your doctor immediately if you feel your condition has worsened or if you are experiencing suicidal thoughts. Be sure to discuss with your doctor any problems you may have and how you feel. This will help your doctor to determine the best treatment for you.

Be sure to keep all of your appointments with your doctor so that your progress can be checked.

Things you must not do

Do not stop taking Aurorix or lower the dose without first checking with your doctor.

Do not let yourself run out of medicine over the weekend or on holidays.

Do not give this medicine to anyone else even if their symptoms seem similar to yours.

Do not use Aurorix to treat other complaints unless your doctor says to.

Things to be careful of

Be careful driving or operating machinery until you know how Aurorix affects you. Aurorix causes dizziness in some people at first.

Although drinking alcohol is unlikely to affect your response to Aurorix, your doctor may suggest avoiding alcohol while you are being treated for depression.

After taking Aurorix


Keep Aurorix where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Keep Aurorix in a cool dry place where the temperature stays below 30°C. Do not store it, or any other medicine, in the bathroom or near a sink. Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines.

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister, they may not keep well.


If your doctor tells you to stop taking Aurorix, or the tablets have passed their expiry date, ask your pharmacist what to do with any tablets that are left over.

Schedule of Aurorix

Aurorix is a Schedule 4 (prescription only) medicine.

Side effects of Aurorix

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Aurorix. Aurorix helps most people with depression, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

In the first week or two you may experience:

  • Sleep disturbances, dizziness, nausea, headache, dry mouth;
  • Occasionally, the symptoms of depression may include thoughts of suicide or self-harm. These symptoms may continue or get worse during the first one to two months of treatment until the full antidepressant effect of the medicine becomes apparent. This is more likely to occur if you are a young adult i.e. under 24 years of age.

Contact your doctor or a mental health professional right away, or go to Accident and Emergency at your nearest hospital for treatment if you or someone you know is demonstrating any of the following warning signs of suicide while taking Aurorix:

  • Thoughts or talk of death or suicide;
  • Thoughts or talk of self-harm or harm to others;
  • Any recent attempts of self-harm;
  • Increase in aggressive behaviour, irritability or agitation;
  • Worsening of depression;
  • Insomnia, nervousness, jitteriness;
  • Mania or hypomania (or onset of early symptoms).

All thoughts or talk of suicide or violence must be taken seriously.

Tell your doctor if you notice any of the following and they worry you:

  • Insomnia;
  • Disturbed sleep;
  • Restlessness;
  • Dizziness;
  • Nausea;
  • Headache;
  • Anxiety;
  • Agitation;
  • Feeling of confusion;
  • Diarrhoea;
  • Vomiting;
  • Paraesthesia;
  • Constipation;
  • Feeling of fullness;
  • Upset stomach;
  • Dry mouth;
  • Blurred vision;
  • Skin rash;
  • Flushing.

This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects not yet known. Tell your doctor if you notice anything else that is making you feel unwell, even if it is not on this list.

Ask your doctor or pharmacist if you don’t understand anything in this list.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

For further information talk to your doctor.


  1. Aurorix Consumer Medicine Information (CMI). St Leonards, NSW: MEDA Pharmaceuticals Pty Ltd. September 2014. [PDF]
  2. Aurorix Product Information (PI). St Leonards, NSW: MEDA Pharmaceuticals Pty Ltd. April 2017. [PDF]

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Posted On: 22 July, 2003
Modified On: 8 March, 2018
Reviewed On: 8 March, 2018


Created by: myVMC