Generic Name: Amoxycillin trihydrate; Potassium clavulanate
Product Name: Augmentin
- Hospital acquired pneumonia
- Recurrent urinary tract infection
- Bites and clenched fist injuries
- Otitis media (unresponsive to amoxicillin)
- Bactericidal; penicillins interfere with bacterial cell wall peptidoglycan synthesis.
- Moderate spectrum penicillins like amoxicillin are active primarily against gram positive organisms.
- The addition of clavulanic acid to amoxicillin extends spectrum of activity to cover many beta-lactamse producing gram positive (S. aureus) and gram negative organisms (Moraxella Catarrhalis, H. Influenzae, Proteus spp., E. coli, Klebsiella spp.), including gram negative anaerobes.
- Oral liquid (powder for) Amoxicillin 25mg/mL, Clavulanic acid 6.25mg/mL, 75mL
- Doses are based on the amoxicillin component.
- 250-500mg every 8 hours (or using Duo formulations: 500-875 mg every 12 hours) for 5-10 days.
- 7.5-15mg/kg every 8 hours (or using Duo formulations 22.5mg/kg every 12 hours) for 5-10 days.
Moderate renal impairment
- give normal initial dose then 500mg every 12 hours
Severe renal impairment
- give normal initial dose then 500mg every 24 hours
Common side effects
- Penicillins are generally well tolerated
- Superinfection- especially during prolonged treatment and/or broad spectrum antibiotics
- Transient increases in liver enzymes and bilirubin
Uncommon side effects
- Exfoliative dermatitis
- Stevens Johnson Syndrome
- Toxic epidermal necrolysis
- Pseudomembranous colitis
For further information talk to your doctor.