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Augmentin

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Generic Name: Amoxycillin trihydrate; Potassium clavulanate
Product Name: Augmentin

Indication

Action

  • Bactericidal; penicillins interfere with bacterial cell wall peptidoglycan synthesis.
  • Moderate spectrum penicillins like amoxicillin are active primarily against gram positive organisms.
  • The addition of clavulanic acid to amoxicillin extends spectrum of activity to cover many beta-lactamse producing gram positive (S. aureus) and gram negative organisms (Moraxella Catarrhalis, H. Influenzae, Proteus spp., E. coli, Klebsiella spp.), including gram negative anaerobes.

Dose advice

  • Oral liquid (powder for) Amoxicillin 25mg/mL, Clavulanic acid 6.25mg/mL, 75mL
  • Doses are based on the amoxicillin component.

Adult:

  • 250-500mg every 8 hours (or using Duo formulations: 500-875 mg every 12 hours) for 5-10 days.

Child:

  • 7.5-15mg/kg every 8 hours (or using Duo formulations 22.5mg/kg every 12 hours) for 5-10 days.

Moderate renal impairment

Adult:

  • give normal initial dose then 500mg every 12 hours

Severe renal impairment

Adult:

  • give normal initial dose then 500mg every 24 hours

Schedule

S4

Common side effects

  • Penicillins are generally well tolerated
  • Diarrhoea
  • Nausea
  • Rash
  • Urticaria
  • Superinfection- especially during prolonged treatment and/or broad spectrum antibiotics
  • Transient increases in liver enzymes and bilirubin

Uncommon side effects

For further information talk to your doctor.

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Dates

Posted On: 22 July, 2003
Modified On: 22 November, 2015

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Created by: myVMC