LoginBRCA2 Mutations Linked to Familial Pancreatic Cancer
The findings of a recent study suggest that BRCA2 mutations play an important role in a subgroup of families with a predisposition to develop pancreatic cancer.
The study involved 26 European families in which at least 2 family members had histologically verified pancreatic cancer. Lymphocyte DNA was taken from participating family members and analysed for BRCA2 germline mutations.
The overall prevalence of BRCA2 mutations was 19%. This finding has immediate implications for the genetic counseling and clinical screening of individuals from kindreds with at least two first-degree relatives affected with histologically confirmed ductal carcinomas of the pancreas.
(Source: Journal of the National Cancer Institute 2003; 95:214-221)
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Posted On: 7 February, 2003
Modified On: 3 December, 2013
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