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Generic Name: Imipramine hydrochloride
Product Name: Tofranil



Tricyclic antidepressants (TCA’s) exert their effects by inhibiting reuptake of noradrenaline and serotonin into presynaptic terminals.

Dose advice

Depression, Panic disorder:

  • 25-75mg daily, increasing by 25-50mg every 2-3 days to 75-150mg daily. Maximum 300mg daily.Urinary urge incontinence:
  • 10-25mg 1-3 times daily


  • Child > 5 years, 10mg twice daily, increased slowly as clinically indicated in increments of 0.5mg/kg to a daily maximum of 3mg/kg, given in 2 or 3 divided doses.
  • In ADHD, serum concentrations do not correlate with therapeutic effects, but may be monitored to minimize toxicity.

Nocturnal enuresis:

  • Child 7-10 years: 10-20mg, 30-60 minutes before bedtime; maximum period of treatment is 3 months.
  • Child >10 years: 25-50mg 30-60 minutes before bedtime; maximum period of treatment is 3 months.
  • Do not use for enuresis in children < 7 years.



Common side effects

  • Sedation
  • Dry mouth
  • Blurred vision
  • Constipation
  • Weight gain
  • Orthostatic hypotension
  • Urinary hesitancy or retention
  • Reduced gastrointestinal motility
  • Anticholinergic delirium (particularly in the elderly and in Parkinson’s disease)
  • Impotence
  • Loss of libido
  • Other sexual adverse effects
  • Tremor
  • Dizziness
  • Sweating
  • Agitation
  • Insomnia

Uncommon side effects

  • Slowed cardiac conduction
  • T wave inversion or flattening (particularly at high doses)
  • Arrhythmias
  • Sinus tachycardia
  • Nausea
  • Hyperglycaemia
  • Gynaecomastia in males
  • Breast enlargement and galactorrhoea in females
  • Allergic skin reactions
  • Manic episodes


  • Blood dyscrasias
  • Hepatitis
  • Parlytic ileus
  • SIADH with hyponatraemia
  • Seizures

For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 18 March, 2016

Created by: myVMC