Are you a Health Professional? Jump over to the doctors only platform. Click Here

Metoprolol (Terry White Chemists)

Print Friendly, PDF & Email

Generic Name: Metoprolol tartrate
Product Name: Metoprolol (Terry White Chemists)

Indication

Metoprolol is used for:

 

Action

  • Atenolol, a type of beta-1-selective-beta-Blocker, competitively blocks beta- adrenoceptors in the heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
  • The antihypertensive effect works by reducing cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretionmay also contribute.
  • The antianginal effect is due to reductionin left ventricular work and oxygen use, resulting from decrease in heart rate and contractility.
  • The antiarrhythmic properties are due to antisympathetic effects: depression of sinus node function and atrio-ventricular conduction and prolongation of atrial refractory periods.
  • Atenolol, a beta-1-selective blocker, has a higher affinity for beta-1 receptors in the heart with less effect on beta-2 receptorsin bronchi and peripheral vasculature.

Dose advice

Hypertension:

  • Oral: initially 50-100mg once daily for 1 Week; maintenance 50-100mg once or twice daily.

Angina:

  • Oral: initially 25-50mg twice daily; maintenance 50-100mg 2-3 times daily.

Tachyarrhythmias:

  • Oral: 50-100mg 2-3 times daily.IV: 5mg (1mg/minute), repeated at 5 minute intervals up to a maximum of 20mg.

Myocardial Infarction:

  • Initially, IV 5mg at 5 minute intervals to a total of 15mg, then 25-50mg orally every 6 hours for 48 hours.
  • Maintenance, oral 50- 100mg twice daily

Prevention of migraine:

  • Oral: 50-75mg twice daily

Schedule

S4

Common side effects

  • Nausea
  • Diarrhoea
  • Bronchospasm
  • Dyspnoea
  • Cold extremities
  • Exacerbation of Raynaud’s Syndrome
  • Bradycardia
  • Hypotension
  • Heart failure
  • Heart block
  • Fatigue
  • Dizziness
  • Abnormal vision
  • Decreased concentration
  • Hallucinations
  • Insomnia
  • Nightmares
  • Depression
  • Altered glucose and lipid metabolism

Uncommon side effects

For further information talk to your doctor.

Print Friendly, PDF & Email

Dates

Posted On: 22 July, 2003
Modified On: 25 April, 2016


Created by: myVMC