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Leukeran

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Generic Name: Chlorambucil
Product Name: Leukeran

Indication

Chlorambucil is used in the treatment of:

Action

Chlorambucil acts by preventing replication of tumour cells by forming cross-linkages between DNA strands.

Dose advice

Specialist protocols should be consulted.For the treatment of neoplasms initial doses of 100-200 micrograms/kg per day orally have been used if Chlorambucil is used as a single agent.

Further courses and doses depend on the individual patient’s response and side effects.

If Chlorambucil is used as an immunosuppressant 100-200 micrograms/kg is given once daily orally. Renal impairment: Doses should be reduced in patients with moderate to severe renal impairment. If creatinine clearance is less than 20 ml/minute, doses should be halved.

Pregnancy: Chlorambucil can cause spontaneous abortion, foetal loss and birth defects and should be avoided during pregnancy. It should also be avoided during breastfeeding.

Schedule

S4

Common side effects

  • Bone marrow suppression.
  • Hair loss.
  • Increased sensitivity of skin to light.

Uncommon side effects

  • Abdominal discomfort.
  • Nausea.
  • Vomiting.
  • Diarrhoea.
  • Mouthy ulceration.
  • Hallucinations.

For further information talk to your doctor.

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Dates

Posted On: 22 July, 2003
Modified On: 31 October, 2015

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Created by: myVMC