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Daraprim

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Generic Name: Pyrimethamine
Product Name: Daraprim

Indication

Used for the treatment of acquired and congenital toxoplasmosis

Action

Pharmacology.

Pyrimethamine disrupts protozoal (e.g. toxoplasmosis) cell function.

Pharmacokinetics.

Peak plasma levels are achieved 2-4 hours after oral administration. Half life is approximately 90 hours.

Dose advice

Adults, Children > 6 years.
Daraprim: 2 tablets initially, then 1 tablet daily. (Coadminister Sulfadiazine 150 mg/kg/day)

Children.
2-6 years: 1 tablet initially, then ½ tablet daily. (Coadminister Sulfadiazine 150 mg/kg/day)
10 months â?? 2 years: ½ tablet daily. (Coadminister Sulfadiazine 150 mg/kg/day)

Infants.
3-9 months: ¼ tablet daily. (Coadminister Sulfadiazine 100 mg/kg/day)
< 3 months: ¼ tablet, on alternate days. (Coadminister Sulfadiazine 100 mg/kg/day)

Use in pregnancy. (Category B3) Pyrimethamine crosses the placenta, and although there is no reports to suggest teratogenicity, caution should be exercised. Folic acid supplementation should be given if pyrimethamine is used during pregnancy.
Treatment should be considered in all cases of toxoplasmosis infections during pregnancy.

Use in lactation. Pyrimethamine is excreted in breast milk. Breastfeeding should be avoided during treatment.

Schedule

S4

Common side effects

Nausea, colic, vomiting, diarrhoea.

Uncommon side effects

Headache, giddiness, dry mouth or throat
Fever, malaise.
Dermatitis, abnormal skin pigmentation

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For further information talk to your doctor.

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Dates

Posted On: 22 July, 2003
Modified On: 1 January, 1970


Created by: myVMC