Anselol
Generic Name: Atenolol
Product Name: Anselol
Indication
Anselol is used in:
- Angina
- Tachyarrhythmias
- Myocardial infarction
- Prevention of migraine
Action
- Atenolol, a type of beta-1-selective-beta-Blocker, competitively blocks beta- adrenoceptors in the heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
- The antihypertensive effect works by reducing cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretion may also contribute.
- The antianginal effect is due to reductionin left ventricular work and oxygen use, resulting from decrease in heart rate and contractility.
- The antiarrhythmic properties are due to antisympathetic effects: depression of sinus node function and atrio-ventricular conduction and prolongation of atrial refractory periods.
- Atenolol, a beta-1-selective blocker, has a higher affinity for beta-1 receptors in the heart with less effect on beta-2 receptors in bronchi and peripheral vasculature.
Dose advice
Hypertension, Angina, Migraine: Prevention:
- Oral: 25-100mg once daily
Tachyarrhthmias:
- Oral: 50-100mg once daily
- IV: 2.5mg (1mg/minute), repeate after 5 minutes if required
- IV infusion: 0.15mg/kg over 20 minutes; repeat after 12 hours if necessary.
Myocardial infarction:
- Initially, IV 5-10mg (1mg/minute), followed by 50mg orally 15 minutes and 12 hours later; then 100mg once daily for 2 days.
- Maintenance, oral 50mg daily.
Schedule
S4
Common side effects
- Nausea
- Diarrhoea
- Bronchospasm
- Dyspnoea
- Cold extremities
- Exacerbation of Raynaud’s Syndrome
- Bradycardia
- Hypotension
- Heart failure
- Heart block
- Fatigue
- Dizziness
- Abnormal vision
- Decreased concentration
- Hallucinations
- Insomnia
- Nightmares
- Depression
- Altered glucose and lipid metabolism
Uncommon side effects
- Rash
- Exacerbation of psoriasis
- Impotence
- Muscle cramp
- Acute urinary retention
- Nasal congestion
- Hypersensitivity reaction
- Thrombocytopenic purpura
- Liver function abnormality
- Alopecia
- Cardiac arrest
- Hepatic injury
For further information talk to your doctor.
Dates
Posted On: 22 July, 2003
Modified On: 19 March, 2016
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