Anselol

Generic Name: Atenolol
Product Name: Anselol

Indication

Anselol is used in:

• Angina
• Tachyarrhythmias
• Myocardial infarction
• Prevention of migraine

Action

• Atenolol, a type of beta-1-selective-beta-Blocker, competitively blocks beta- adrenoceptors in the heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
• The antihypertensive effect works by reducing cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretion may also contribute.
• The antianginal effect is due to reductionin left ventricular work and oxygen use, resulting from decrease in heart rate and contractility.
• The antiarrhythmic properties are due to antisympathetic effects: depression of sinus node function and atrio-ventricular conduction and prolongation of atrial refractory periods.
• Atenolol, a beta-1-selective blocker, has a higher affinity for beta-1 receptors in the heart with less effect on beta-2 receptors in bronchi and peripheral vasculature.

Dose advice

Hypertension, Angina, Migraine: Prevention:

• Oral: 25-100mg once daily

Tachyarrhthmias:

• Oral: 50-100mg once daily
• IV: 2.5mg (1mg/minute), repeate after 5 minutes if required
• IV infusion: 0.15mg/kg over 20 minutes; repeat after 12 hours if necessary.

Myocardial infarction:

• Initially, IV 5-10mg (1mg/minute), followed by 50mg orally 15 minutes and 12 hours later; then 100mg once daily for 2 days.
• Maintenance, oral 50mg daily.

Schedule

S4

Common side effects

• Nausea
• Diarrhoea
• Bronchospasm
• Dyspnoea
• Cold extremities
• Exacerbation of Raynaud’s Syndrome
• Bradycardia
• Hypotension
• Heart failure
• Heart block
• Fatigue
• Dizziness
• Abnormal vision
• Decreased concentration
• Hallucinations
• Insomnia
• Nightmares
• Depression
• Altered glucose and lipid metabolism

Uncommon side effects

• Rash
• Exacerbation of psoriasis
• Impotence
• Muscle cramp
• Acute urinary retention
• Nasal congestion
• Hypersensitivity reaction
• Thrombocytopenic purpura
• Liver function abnormality
• Alopecia
• Cardiac arrest
• Hepatic injury

For further information talk to your doctor.