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Generic Name: Dacarbazine
Product Name: D.T.I.C


Darcarbazine is used in the treatment of the following tumours:- Metastatic malignant melanoma- Ewing’s sarcoma- Rhabdomyosarcoma – Hodgkin’s disease


Dacarbazine interferes with cellular replication by forming cross-linkages between DNA strands.

Dose advice

Specialist protocols should be consulted concerning dosages:Melanoma:- An initial dose that may be used is 250 mg/m2 daily given by intravenous infusion on days 1-5 of each 21-day cycle. – Alternatively, 800 mg/m2 can be given on day 1 of each 21-day cycle.- These doses may be used in single or combination therapy.- Subsequent doses depend on the individual patient’s response and the severity of adverse effects.Hodgkin’s disease:- Dacarbazine is used in combination treatment with other antineoplastic agents.- 150 mg/m2 each day given by intravenous infusion on days 1?5 of each 28-day cycle.- Alternatively, 375 mg/m2 can be given on day 1 and day 15 of each 28-day cycle.



Common side effects

- Bone marrow suppression- Nausea- Vomiting- Diarrhoea- Fever- Muscle aches- Fatigue- Facial flushing- Pain along the injected vein

Uncommon side effects

- Low white cell count- Blurred vision- Hair loss- Confusion- Headache- Rash- Increased sensitivity of skin to light- Seizures


For further information talk to your doctor.


Posted On: 22 July, 2003
Modified On: 30 January, 2014

Created by: myVMC
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