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Generic Name: Dacarbazine
Product Name: D.T.I.C


Darcarbazine is used in the treatment of the following tumours:


Dacarbazine interferes with cellular replication by forming cross-linkages between DNA strands.

Dose advice

Specialist protocols should be consulted concerning dosages:


  • An initial dose that may be used is 250 mg/m2 daily given by intravenous infusion on days 1-5 of each 21-day cycle
  • Alternatively, 800 mg/m2 can be given on day 1 of each 21-day cycle
  • These doses may be used in single or combination therapy
  • Subsequent doses depend on the individual patient’s response and the severity of adverse effects.

Hodgkin’s disease

  • Dacarbazine is used in combination treatment with other antineoplastic agents
  • 150 mg/m2 each day given by intravenous infusion on days 1-5 of each 28-day cycle
  • Alternatively, 375 mg/m2 can be given on day 1 and day 15 of each 28-day cycle.



Common side effects

Uncommon side effects

  • Low white cell count
  • Blurred vision
  • Hair loss
  • Confusion
  • Headache
  • Rash
  • Increased sensitivity of skin to light
  • Seizures

For further information talk to your doctor.


Posted On: 22 July, 2003
Modified On: 20 November, 2015


Created by: myVMC