Generic Name: Trimethoprim
Product Name: Alprim
Indication of Alprim
Used for the treatment of acute urinary tract infections caused by organisms susceptible to Trimethoprim
Action of Alprim
Trimethoprim inhibits bacterial nucleic acid and protein biosynthesis.
It is active against the pathogens commonly responsible for urinary tract infections (e.g. E.coli, P.mirabilis, K.pneumoniae).
Trimethoprim is found in vaginal secretions and faeces, and can suppress normal vaginal and bowel flora.
It is not active against Pseudomonas sp.
Developing resistance is more likely to occur in hospital than in domicillary use.
Trimethoprim is rapidly absorbed from the gut, with a half life of 8-12 hours (in patients with normal renal function).
Excretion is primarily in the urine, 80% of the dose is excreted unchanged.
Dose advice of Alprim
1 tablet, daily, for 7 days
6 â 12 years: Half a tablet, daily, for 7 days.
< 6 years: The appropriate dose in children of this age is not yet established.
Impaired renal or hepatic function.
Use with caution in patients with renal or hepatic insufficiency.
Use in pregnancy
Use in lactation.
Trimethoprim is excreted in breastmilk, it should not be used in breastfeeding women.
Schedule of Alprim
Common side effects of Alprim
Nausea, vomiting, abdominal discomfort, glossitis.
Low blood counts (thrombocytopenia, leucopenia, neutropenia, megaloblastic anaemia), methaemoglobinaemia
Uncommon side effects of Alprim
Changes in hepatic and renal biochemistry.
For further information talk to your doctor.