LoginDuride
Generic Name: isosorbide mononitrate
Product Name: Duride
Indication: What Duride is used for
Duride is used to prevent angina.
Your doctor may have prescribed Duride for another reason. Ask your doctor if you have any questions about why Duride has been prescribed for you.
Duride is not recommended for use in children, as there is not enough information available on its effects in children.
Duride is available only with a doctor’s prescription.
There is no evidence that Duride is addictive.
Action: How Duride works
Duride belongs to a group of medicines called nitrates. These medicines work by widening blood vessels, letting more blood and oxygen reach the heart.
Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. It has qualitatively similar effects. Isosorbide mononitrate reduces the workload of the heart by producing venous and arterial dilatation. It lowers intramural pressure by reducing the end diastolic pressure and volume. This leads to an improvement in the subendocardial blood flow. When isosorbide mononitrate is administered, the net effect is, therefore, a reduced workload for the heart and an improvement in the oxygen supply/demand balance of the myocardium.
The active ingredient in Duride is isosorbide mononitrate. Each Duride tablet contains 60 mg of isosorbide mononitrate.
The tablets also contain colloidal anhydrous silica, heavy kaolin, magnesium stearate, microcrystalline cellulose, hard paraffin, synthetic paraffin, and Opadry Yellow OY-LS-22814 (includes colours iron oxide red CI 77491, iron oxide black CI 77499, iron oxide yellow CI 77492, titanium dioxide CI 77891). The tablets are gluten free.
Dose advice: How to use Duride
How to take Duride
How much to take
The usual dose is one tablet once a day. Some patients may need a different dose. Your doctor will decide the right dose for you.
Follow all directions given to you by your doctor and pharmacist carefully.
How to take it
Swallow the tablets whole with half a glass of water.
Duride tablets can be broken in half if care is taken not to crumble them. Please break the tablet in half with care if your doctor has prescribed half a tablet.
Do not crush or chew the tablets.
Duride tablets are sustained release. This means the medicine is released into the blood over an extended period of time. If you crush or chew Duride tablets, they will not work as well.
When to take it
Duride can be taken with or without food.
Take your tablets at about the same time each day.
This helps them to control your angina properly.
If your doctor tells you to take two tablets each day, take both tablets at the same time.
Taking Duride at 24-hour intervals helps to keep them working properly.
If you forget to take it
If it is more than 8 hours since you should have taken your dose, do not take the missed dose, wait until the right time the next day to take your next dose.
Otherwise, take the missed dose as soon as you remember, and then go back to taking your tablets as you would normally.
Do not take a double dose to make up for the dose you missed.
If you miss a dose of Duride, you may get attacks of angina and need to use the tablets or spray your doctor has given you for relieving angina attacks.
If you are not sure what to do, ask your doctor or pharmacist.
If you have any questions about this, check with your doctor or pharmacist.
How long to take it for
To prevent angina, Duride must be taken every day.
Keep taking Duride for as long as your doctor recommends.
Duride helps to control your angina but does not cure it. It is important to keep taking it even if you feel well.
If you take too much of it (overdose)
Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26), or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Duride. Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
If you take too much Duride, you may have a throbbing headache, a fast heartbeat and feel dizzy or faint. You may feel excited, flushed, have cold sweats, feel sick or vomit.
While you are taking Duride
Things you must do
Take Duride regularly once every day.
If you don’t, you will be more likely to get attacks of angina.
If you continue to have angina attacks, or if they become more frequent while you are taking Duride, tell your doctor.
Before starting any new medicine, tell your doctor or pharmacist that you are taking Duride.
Tell all the doctors, dentists and pharmacists who are treating you that you are taking Duride.
If you become pregnant while taking Duride, tell your doctor.
Visit your doctor regularly so they can check on your progress.
Things you must not do
Do not use Duride to relieve acute attacks of angina.
Duride is used to prevent angina. Your doctor will have given you other tablets or a spray to use if you have an attack of angina.
Do not stop taking Duride, or change the dose, without checking with your doctor. Do not let yourself run out of tablets over the weekend or on holidays.
Stopping Duride suddenly may worsen your angina.
Do not use Duride to treat any other conditions unless your doctor tells you to.
Do not take medicines known as phosphodiesterase type 5 inhibitors used to treat impotence in men, such as: sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) if you are taking Duride.
Taking these two medicines together may cause your blood pressure to drop to a dangerously low level. This may lead to fainting or even a heart attack.
Do not give Duride to anyone else, even if they have the same condition as you.
Things to be careful of
You will probably feel better when you start taking Duride but be careful not to overdo physical activities straight away.
You will need time to improve your physical fitness.
Be careful driving or operating machinery until you know how Duride affects you.
Duride may cause dizziness, lightheadedness or fainting in some people. If any of these occur, do not drive, operate machinery or do anything that could be dangerous.
Be careful getting up from a sitting or lying position.
Dizziness, lightheadedness or fainting may occur, especially when you get up quickly. Getting up slowly may help.
Be careful when drinking alcohol while taking Duride.
Combining Duride and alcohol can make you more sleepy, dizzy or lightheaded, due to a drop in your blood pressure.
After taking Duride
Be aware that the outer shell of Duride tablets passes through the body. This does not affect the way it works.
Duride tablets are made of a wax-like shell which does not dissolve in the body. After the active ingredient, isosorbide mononitrate, has been absorbed into the body, you may see this empty tablet shell in your faeces (bowel motions).
Storage
Keep Duride where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
Keep your tablets in the blister pack until it is time to take them.
If you take the tablets out of their pack they may not keep well.
Keep your tablets in a cool dry place where the temperature stays below 30°C.
Do not store Duride or any other medicine in the bathroom or near a sink.
Do not leave Duride in the car or on window sills.
Heat and dampness can destroy some medicines.
Disposal
If your doctor tells you to stop taking Duride, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.
Schedule of Duride
Duride is an S4 (Prescription Only Medicine).
Side effects of Duride
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Duride.
Duride helps most people with angina, but it may have unwanted side effects in some people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
- Headache;
- Dizziness, lightheadedness or feeling faint;
- Feeling sick (nausea);
- Rapid heartbeat;
- Poor appetite;
- Vomiting;
- Heartburn;
- Diarrhoea;
- Rash, itching;
- Muscle tenderness or weakness not caused by exercise;
- Tiredness or sleep disturbances.
Headache is the most common side effect with Duride. It can happen when you start treatment but usually goes away in a few days.
These are all mild side effects of Duride.
Other side effects not listed above may also occur in some patients. Tell your doctor if you notice anything that is making you feel unwell.
For further information talk to your doctor.
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