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Deralin

Generic Name: Propranolol hydrochloride
Product Name: Deralin

Indication

Propranolol is used in the treatment of:

  • Heart Attack.
  • Angina.
  • High Blood Pressure.
  • Prevention of Migraines
  • Abnormal heart rhythms which may be due to a number of different causes including hyperthyroidism, anxiety and medications
  • Dysrhythmias associated with thyrotoxicosis
  • Tachycardia due to anxiety
  • Drug induced dysrhythmias
  • Essential tremors including familial and senile tremors
  • Phaeochromocytoma
  • Hypertrophic subaortic stenosis

    Action

    Propranolol acts on the heart to slow the heart rate and reduce the force the heart must pump with. This reduced the heart’s workload and its oxygen requirements.The mechanism by which Propranolol lowers blood pressure is unknown.

    Dose advice

    Adults:Hypertension:

  • The recommended initial dose is 40 mg twice daily.
  • This dose may be increased by 40mg at weekly intervals depending on the individual patient’s response.
  • The usual dose range is 120-320 mg per day.Angina Pectoris:
  • The recommended initial dose is 40 mg twice daily.
  • This dose may be increased by 40mg at weekly intervals depending on the individual patient’s response.
  • The usual dose range is 120-320 mg per day.Essential tremor:
  • The recommended initial dose is 40 mg twice daily.
  • This dose may be increased by 40mg at weekly intervals depending on the individual patient’s response.
  • The usual dose range is 80-160 mg per day.Migraine:
  • The recommended initial dose is 40 mg twice daily.
  • This dose may be increased by 40mg at weekly intervals depending on the individual patient’s response.
  • The usual dose range is 80-160 mg per day and a clinical response should be evident within three months of commencing treatment.
  • If the frequency of migraines is significantly reduced therapy may be gradually ceased as remission may occur in some patients.Cardiac dysrhythmias, anxiety tachycardia, dysrhythmias associated with thyrotoxicosis and hypertrophic subaortic stenosis:
  • 10-40 mg three or four times a day.Phaeochromocytoma:
  • Propranolol is used only in combination with an alpha-receptor blocking drug.
  • Preoperatively: 60 mg daily in divided doses for three days.
  • Maintenance dosing: 30 mg daily in divided doses.Myocardial Infarction:
  • Initial therapy is 40 mg four times a day for two or three days.
  • This may then be changed to 80 mg twice a day in order to improve patient compliance.Children:
  • Doses in children should be individually determined and the following doses are only a guide.Cardiac dysrhythmias:
  • 0.25 to 0.5 mg/kg three or four times daily. Phaeochromocytoma:
  • 0.25 to 0.5 mg/kg three or four times daily. Dysrhythmias due to thyrotoxicosis:
  • 0.25 to 0.5 mg/kg three or four times daily. Fallot’s tetralogy:
  • 1 mg/kg repeated three or four times daily. Migraine:
  • Start with 10 mg once or twice daily.
  • This dose may be increased up to 2 mg/kg bodyweight per day in divided doses.
  • A clinical response should be evident within three months of commencing treatment.
  • As in adults if the frequency of migraines is significantly reduced therapy may be gradually ceased as remission may occur in some patients.

    Schedule

    S4

    Common side effects

  • Loss of appetite
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain

    Uncommon side effects

  • Cold finger and toes
  • Exacerbation of Raynaud’s phenomenon
  • Sleep disturbances including vivid dreams and nightmares
  • Dizziness
  • Weakness
  • Fatigue
  • Vision disturbances
  • Hallucinations
  • Rash
  • Impotence and reduced libido
  • Ringing ears
  • Dry eyes
  • Fever
  • Aching and sore throat
  • Flushing of the face
  • Hair loss

     

    For further information talk to your doctor.

  • Dates

    Posted On: 22 July, 2003
    Modified On: 30 January, 2014


    Created by: myVMC