Study of Long-Term Living Kidney Donors

This study is designed to quantify the long-term medical and psychosocial implications of living kidney donation. The short-term consequences of living donation are well established. On the other hand the long-term consequences of living kidney donation are far less certain. The main medical concerns of living kidney donation include an increased risk of hypertension, proteinuria, and low glomerular filtration rate (GFR- a measure of the filtering capacity of the kidney). Estimates of these outcomes are variable, inconsistent, and uncertain in the literature.

Official Title

The Long-Term Medical and Psychological Implications of Becoming a Living Kidney Donor: A Historical Matched Cohort Study

Conditions

Kidney Diseases

Study Type

Observational

Study Design

Natural History, Longitudinal, Defined Population, Retrospective Study

Further Details

Study Start

May 2004; Expected completion: December 2007

Eligibility & Criteria

• Ages Eligible for Study: 18 Years and above
• Genders Eligible for Study: Both
• Accepts Healthy Volunteers

Inclusion Criteria:

• Age greater than 18 years old
• Living kidney transplant occurred between 1970 and 2005
• At least one GFR assessment at baseline (by predictive equation, 24 hour creatinine clearance, or radio-nuclear technique) and no evidence of a GFR less than 80 mL/min/1.73m² with any measurement
• At least one history and blood pressure measurement at baseline, with no evidence of:a history of hypertension or use of antihypertensive class medications for any reason
• At least one assessment of urine protein at baseline (by 24 hour urine, random urine dipstick, random urine protein to creatinine ratio, or early morning urine protein) with no evidence of: a 24 hour urine protein greater than 150 mg/day, a random or morning urine albumin to creatinine ratio greater than 37.8 mg/mmol, a random or morning urine albumin concentration greater than 33.6 mg/L, or a random or morning urine dipstick protein result of 0.3 g/L (1+) or greater

Exclusion Criteria:

• The eligible non-donor had a medical condition (such as cardiovascular disease, pulmonary disease, or active cancer) which made them unfit to donate. Blood group and immunological incompatibility (such as positive cross-match, poor HLA matches) are not reasons for exclusion.
• The eligible non-donor subsequently went on to donate a kidney
• The donor and the eligible non-donor had their transplantation work-up over 2 years apart
• Either the donor or the eligible non-donor are unable to give informed consent
• Either the donor or eligible non-donor are unwilling to come to a transplant centre for assessment
• An incomplete pair of a living donor and an eligible non-donor
• The living donor or eligible non-donor is currently pregnant

Total Enrolment

100

Contact Details

Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009, Australia; Recruiting

• Tory Roberts tory.roberts@health.wa.gov.au
• Lesley Hayes lesley.hayes@health.wa.gov.au

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