Rationale: Learning about pesticides in the households of young patients with leukaemia and in the households of healthy volunteers may help scientists better understand the risk of leukaemia.Purpose: This epidemiology study is identifying environmental factors related to the risk of leukaemia in the households of healthy volunteers and in the households of young patients with leukaemia.

Official Title

 

A Case-Control Study of Pesticides and Childhood Leukemia.

Conditions

  •  Leukaemia

Study Type

Observational

Study Design

Primary Outcome Measures:

  • Identification of environmental factors that may increase the risk of leukaemia in children

Objective:

  • To identify environmental factors that may increase the risk of leukaemia in children.

Outline:

Approximately 3-6 months after completing the tier I interview on a separate NCI epidemiologic study, participants undergo a tier II interview and home assessment over 1 hour to identify the presence of certain chemical compounds (e.g. pollutants, pesticides, and automobile exhaust) in their home environment. Participants are evaluated for exposure to these compounds through a survey of household products used and through collection of environmental samples. Samples of dust from the participant’s vacuum cleaner bag or windowsill are obtained for analysis, as well as air samples obtained via an air monitor which is placed in the home for two weeks and then forwarded to the study laboratory for analysis. Pesticide-treated crops grown within a 1,200 meter radius of the house are mapped.

Further Details

Study Start

October 2001

Eligibility & Criteria

  • Genders Eligible for Study: Both
  •  

    Accepts Healthy Volunteers: Yes

Disease Characteristics:

  • Meets 1 of the following criteria:
    • Household of a pediatric leukaemia patient (age 0-7 years) who was diagnosed with leukaemia after December 1, 1999
    • Household of a matching healthy participant (age 0-7 years)
  • Resides in the San Francisco Bay area and the agricultural Central Valley of California
  • Resides at the same home where they were living at the time of diagnosis
  • Must have completed a previous (tier I) interview as part of an ongoing University of California at Berkeley epidemiologic study

Patient Characteristics:

  • At least 1 parent speaks English or Spanish
  • No prior cancer diagnosis.

Total Enrolment

620

Contact Details

Location:

National Cancer Institute
6116 Executive Boulevard
Room 3036A
Bethesda, MD 20892-8322

Contact:

POC: Mary H. Ward, PhD
Phone No.: 1-800-422-6237

 

     

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