Are you a Health Professional? Jump over to the doctors only platform. Click Here

Reversing resistance to kidney cancer treatment

Print Friendly, PDF & Email

Van Andel Research Institute (VARI) researchers have found a way to reverse resistance to sunitinib, a treatment that is currently the first line of defense against clear cell renal cell carcinoma (ccRCC), a deadly form of kidney cancer.  Most patients who show a positive response to sunitinib develop a resistance to the drug after one year of treatment.

Kidney cancer is among the 10 most common cancers in both men and women, striking nearly 50,000 Americans in 2009 and killing more than 11,000. Renal cell carcinoma (RCC) accounts for 9 out of 10 kidney cancers, and ccRCC is the most common subtype, accounting for 8 out of 10 RCC cases.

"The research from Dr Teh’s (VARI) group is a critical step forward in understanding the mechanisms of response and resistance to the new standard of care therapies in renal cell carcinoma such as sunitinib," said Brian Rini, MD, Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute.

Sunitinib received FDA approval in 2006 and is a standard of care for both ccRCC and gastrointestinal stromal tumours. The drug is being investigated as a possible therapy for other cancers, including breast cancer, colorectal cancer, and non small cell lung cancer.

Researchers found that ccRCC tumour cells that had developed a resistance to sunitinib had increased secretion of the protein interleukin 8 (IL 8).  Administering sunitinib and IL 8 neutralising antibodies resensitised tumours to sunitinib treatment.  Researchers also found that IL 8 may serve as a useful biomarker to predict patients’ response to sunitinib treatment.

"The development of ccRCC resistance to sunitinib treatment is of major clinical concern," said VARI Distinguished Scientific Investigator Bin Tean Teh, MD, PhD, whose laboratory published its findings in this month’s issue of Cancer Research.  "It is now of critical importance to validate these findings in the clinical setting."

Another study from Teh’s laboratory also published in Cancer Research this month looked into exactly how sunitinib works.  The study found that the treatment does not target tumour cells, but rather the tumour’s blood supply.


"Understanding how sunitinib works should have important implications for the improved treatment of ccRCC and perhaps other cancers as well," said VARI Postdoctoral Fellow Dan Huang, PhD, lead author of both studies.

"These insights will help build upon recent advances to extend clinical benefits to more patients with metastatic kidney cancer," said Dr Rini. 

Dr Rini is a paid consultant of and has a research funding relationship with Pfizer, Inc., which partially funded this study.

(Sources: Van Andel Institute: Cancer Research: February 2010)


Print Friendly, PDF & Email

Dates

Posted On: 22 February, 2010
Modified On: 16 January, 2014

Tags



Created by: myVMC