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Control Acid Reflux to Prevent Oesophageal Cancer

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Increase in obesity linked to rising numbers of oesophageal cancer cases.

For most of his adult life, 49-year-old Jim Bonell suffered from acid reflux, but he never considered the condition dangerous. That is, until he was diagnosed with oesophageal cancer. What Bonell didn’t know was that his chronic acid reflux left him with a condition called Barrett’s oesophagus, which puts people at high risk for oesophageal cancer. Barrett’s is a condition in which the cells lining the lower oesophagus change because of repeated exposure to stomach acid. Normally, the tissue lining the oesophagus is similar to the lining in your mouth (squamous mucosa), but with Barrett’s, the body replaces the normal oesophageal lining with one similar to that found in the intestines.”There were no symptoms that I had oesophageal cancer,” says Bonell. “Prior to being diagnosed, my acid reflux was really bad and getting worse. I was a Tums-eater. I’d eat a whole bunch of them.”Oesophageal cancer rates are on the rise, and the increase may be due to an increase in obesity, says Mark B. Orringer, M.D. professor and head of thoracic surgery at the University of Michigan Health System. Obesity often causes a hiatus hernia and associated acid reflux.Oesophageal cancer has always carried a terrible prognosis. But thanks to an increasing awareness that heartburn may have serious implications along with earlier detection, improved staging tests and better treatment many patients like Bonell are winning the battle with this initially “silent” cancer.Bonell has benefited from some of the surgical advances developed and refined at the U-M Health System. Traditionally, patients who needed to have their oesophagus removed-either for oesophageal cancer or Barrett’s oesophagus – underwent highly invasive surgery that involved opening the chest and abdomen. But Orringer and his colleagues developed a procedure, called transhiatal oesophagectomy, in which the oesophagus is removed through incisions in the abdomen and the neck, without the need to open the chest. Once the oesophagus is removed, the stomach is freed up from attachments holding it in the belly and it is pulled up through the chest. The stomach is then connected to the remaining oesophagus in the neck. The risk of infection is significantly lowered with this procedure because if any leak at the connection in the neck occurs, the resulting infection drains externally rather than in the chest, says Orringer. Further, by avoiding the traditional chest incision, pneumonia after this operation is much less common.”In a recent study of more than 2,000 patients who have undergone a transhiatal oesophagectomy at the University of Michigan, the hospital mortality rate in the last 1,000 patients was 1 percent; that’s one death in 100 operations,” he notes. “When I began as a faculty member in 1973, the mortality for oesophagectomy was as high as 20 percent at many institutions.”This development in surgical treatment is important given the dramatic rise in cancer cases that doctors believe stems from obesity and acid reflux. Twenty years ago, the most common type of oesophageal cancer was squamous cancer, which arises from the squamous mucosa that lines the normal oesophagus.But in the past 10 to 15 years, there has been a 350 percent increase in adenocarcinoma of the oesophagus, a type of cancer that is related to the cellular changes in the oesophagus that are the hallmark of Barrett’s. It is now the most common form of oesophageal cancer, occurring in 80 percent to 90 percent of patients. This increase in oesophageal adenocarcinoma mirrors the rise of the obesity epidemic.”There’s no question that the incidence of oesophageal cancer is increasing dramatically. We have an epidemic of obesity in this country,” says Orringer. “I can’t walk into a social setting where there are not some people who are quite overweight and complain of heartburn or acid indigestion. I think we should be very concerned.”(Source: University of Michigan : July 2007)


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Posted On: 11 July, 2007
Modified On: 16 January, 2014

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