Julie Lin, MD, MPH from the Renal Division at Brigham and Women’s Hospital and colleagues from Harvard Medical School and Harvard School of Public Health report that sICAM-1, a marker of vascular inflammation, is predictive of progressive kidney disease those with type 1 diabetes. These findings appear on the Diabetes Care website in September 2008.
This study is unique in looking at inflammatory biomarkers in relation to repeated measures of albumin excretion into the urine over a 9-year follow up in 1441 participants of the Diabetes Control and Complications Trial (DCCT).
Albumin is a protein not normally present in urine, and albuminuria is an important predictor of progressive kidney problems and heightened cardiovascular risk in type 1 diabetics.
The investigators report that higher baseline levels of plasma biomarker sICAM-1 was associated with increasing albuminuria over time as well as with the development of new clinically significant albuminuira in type 1 diabetics without this condition at baseline.
The results are important in potentially allowing for earlier prediction and risk stratification of kidney disease, a major source of morbidity in type 1 diabetes.
(Source: Diabetes Care: Brigham and Women’s Hospital: October 2008)