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Generic Name: Drotrecogin alfa
Product Name: Xigris


Xigris is a fibrinolytic agent used for to reduce mortality in adult patients with severe, life threatening sepsis.


  • Xigris (dogrecogin alfa) is human activated protein C made with recombinant DNA technology, it has similar properties to natural human activated protein C.
  • Activated protein C increases the breakdown of blood clots and has anti-inflammatory activity.
  • 90% of the steady state condition is achieved within two hours of commencing an infusion. After the completion of an infusion, activated protein C concentrations exhibit a biphasic half life with a rapid intial phase of 13 minutes, and a slower second phase of 1.6 hours.
  • The mechanism by which activated protein C is cleared from the plasma is unknown.

Dose advice

Continuous infusion: 24 microgram/kg/hour, over 96 hours.



Common side effects

  • Bruising.
  • Increased bleeding

Uncommon side effects

  • Serious bleeding (e.g. intracranial haemorrhage, life threatening bleeding or bleeding requiring transfusion of at least 3 units of packed red cells per day for two days) occurs in about 3.5% of patients.

For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 13 May, 2016

Created by: myVMC