Tobramycin Injection BP
Generic Name: Tobramycin sulfate
Product Name: Tobramycin Injection BP
Indication
Tobramycin sulfate can be used to treat a number of serious bacterial infections. It is most commonly used for treating respiratory tract infections, skin infections, urinary tract infections, and infections of the blood, abdomen or bones. It is given by injection since oral absorption is poor.
Action
Tobramycin sulfate and other aminoglycoside antibiotics kill sensitive strains of bacteria by interfering with the production of proteins, essential to the survival of the bacteria.
Dose advice
– Tobramycin Injection BP may be given intravenously or intramuscularly (dosage is the same)
– Usual duration of treatment is 7 – 10 days. A longer duration of treatment may be necessary in complicated infections but should always be accompanied by renal, auditory and vestibular monitoring due to the potential for toxic effects.
– Adults: serious infections – 3 mg/kg/day in three doses given every eight hours. Mild to moderate urinary tract infections: 2 to 3 mg/kg/day in two or three equally divided doses.
– Children and older infants: 6 to 7.5 mg/kg/day in three or four equally divided doses.
– Impaired renal function: Serum tobramycin concentrations should be monitored. A loading dose of 1 mg/kg is usually given and following that, subsequent doses should be reduced.
Schedule
S4
Common side effects
– As with any other medication, Tobramycin sulfate can cause a number of side effects, most of which are likely to be minor and should cease when the drug is stopped. Some of the more common side effects include:
– Minor renal impairment (as measured by laboratory tests)
– Toxic effects on the ears â?? nausea, dizziness, hearing problems, balance problems
Uncommon side effects
– Less common side effects include:
– Electrolyte abnormalities
– Rash and itch
– Nausea and vomiting
– Fever
– Blood abnormalities such as anaemia and reduced numbers of platelets
– fatigue
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For further information talk to your doctor.
Dates
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