Generic Name: Atenolol
Product Name: Tenormin
- Myocardial infarction
- Prevention of migraine
- Atenolol, a type of beta-1-selective-beta-Blocker, competitively blocks beta- adrenoceptors in the heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
- The antihypertensive effect works by reducing cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretionmay also contribute.
- The antianginal effect is due to reductionin left ventricular work and oxygen use, resulting from decrease in heart rate and contractility.
- The antiarrhythmic properties are due to antisympathetic effects: depression ofsinus node function and atrio-ventricular conduction and prolongation of atrial refractory periods.
- Atenolol, a beta-1-selective blocker, has a higher affinity for beta-1 receptors in the heart with less effect on beta-2 receptorsin bronchi and peripheral vasculature.
Hypertension, angina, migraine prevention
- Oral: 25-100mg once daily
- Oral: 50-100mg once daily
- IV: 2.5mg (1mg/minute), repeate after 5 minutes if required
- IV infusion: 0.15mg/kg over 20 minutes; repeat after 12 hours if necessary
- Initially, IV 5-10mg (1mg/minute), followed by 50mg orally 15 minutes and12 hours later; then 100mg once daily for2 days.
- Maintenance, oral 50mg daily
Common side effects
- Cold extremities
- Exacerbation of Raynaud’s Syndrome
- Heart failure
- Heart block
- Abnormal vision
- Decreased concentration
- Altered glucose and lipid metabolism
Uncommon side effects
- Exacerbation of psoriasis
- Muscle cramp
- Acute urinary retention
- Nasal congestion
- Hypersensitivity reaction
- Thrombocytopenic purpura
- Liver function abnormality
- Cardiac arrest
- Hepatic injury
For further information talk to your doctor.