Tamoxifen-BC

Generic Name: Tamoxifen citrate
Product Name: Tamoxifen-BC

Indication

Tamoxifen is used in the palliative treatment of breast cancer that has been shown to express oestrogen receptors.

Action

Tamoxifen is a non-steroidal anti-oestrogen. It probably works by binding to oestrogen receptors, and this inhibits the effects of endogenous oestrogen. Many breast cancers have oestrogen receptors and therefore have their growth stimulated by the presence of oestrogen. By inhibiting oestrogen, Tamoxifen inhibits tumour growth.

Dose advice

Initial dose is 20mg once daily. If no improvement is seen within one month, increase to 40mg daily.

Schedule

S4

Common side effects

• hot flushes
• nausea
• vomiting

Uncommon side effects

• fluid retention
• vaginal bleeding
• vaginal discharge
• vaginal itching
• tumour pain
• tumour flare
• lightheadedness
• headaches
• skin rash
• hair loss
• Increased occurrence of endometrial (lining of uterus) changes have been reported. These range from polyps to cancer.
• Unusual vaginal bleeding should be immediately reported to your doctor.
• Visual changes may occur rarely.

For further information talk to your doctor.