Talohexal

Generic Name: Citalopram hydrobromide
Product Name: Talohexal

Indication

Major depression

Action

Selective inhibition of pre-synaptic uptake of serotonin (5- hydroxytryptamine, 5-HT)
SSRIs inhibit liver cytochrome enzymes responsible for the metabolism of many other drugs, thus potentially interacting with those drugs by decreasing their metabolism

Dose advice

20mg once daily, gradually increasing if necessary to a maximum of 60mg daily (40mg in the elderly).
Maintenance doses > 20mg are not usually necessary

Schedule

Common side effects

Nausea
Agitation
Insomnia
Drowsiness
Tremor
Dry mouth
Diarrhoea
Dizzness
Headache
Sweating
Asthenia
Anxiety
Weight gain or loss
Sexual dysfunction
Rhinitis
Myalgia
Rash

Uncommon side effects

Extrapyramidal reactions (including tartive dyskinesia and dystonia)
Sedation
Confusion
Palpitations
Tachycardia
Hypotension
SIADH
Abnormal platelet aggregation/ haemorrhagic complications (e.g. bruising, epistaxis, purpura)
Rare:
Elevated liver enzymes
Hepatitis
Hepatic failure
Galactorrhoea
Blood dyscrasias
Seizures
Akathesia