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Generic Name: Cyclosporin
Product Name: Sandimmun


Indications for the use of Cyclosporine include:

  • Prevention of organ rejection after kidney, liver, and heart transplantation
  • Severe active rheumatoid arthritis
  • Severe psoriasis
  • Severe atopic dermatitis
  • Autoimmune diseases
  • Nephrotic syndrome
  • Prevention of graft-versus-host disease
  • Potential organ transplant recipients that are receiving a blood transfusion may also require cyclosporine


Cyclosporine acts by preventing the activation of the cells that are responsible for the production of an immune response in the body.

Dose advice

Organ transplantation:

  • 8-15 mg/kg orally per day given as 2 divided doses.If given with diltiazem 5?8 mg/kg orally per day given as 2 divided doses

Autoimmune diseases:

  • 2.5-5 mg/kg orally per day given as 2 divided doses.

Severe ulcerative colitis:

  • 3-5 mg/kg intravenously daily.

Prevention of allogenic graft-versus-host disease:

  • 3 mg/kg intravenously daily until oral treatment can be tolerated.



Common side effects

  • High blood pressure
  • High cholesterol levels
  • Tremor
  • Numbness and tingling in the fingers and toes
  • Increased risk of infection
  • Gum overgrowth
  • Increased body hair
  • Diarrhoea
  • Elevated blood sugar levels
  • Kidney function impairment

Uncommon side effects

  • Headache
  • Muscle weakness

For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 31 October, 2015


Created by: myVMC