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Generic Name: Nitrofurantoin
Product Name: Ralodantin


Used for the treatment of urinary tract infections, including cystitis and pyelonephritis, caused by pathogens susceptible to Nitrofurantoin.



Nitrofurantoin is a synthetic, nitrofuran derivative antibiotic. It is bacteriostatic at low concentrations and bactericidal at higher concentrations.

Nitrofurantoin has activity against common Gram negative and Gram positive urinary tract pathogens.


Nitrofurantoin is well absorbed from the gut, peak plasma levels are achieved within 1-2 hours. The plasma half life is 20 minutes. It is rapidly excreted in the urine, chiefly in the unchanged form.

Dose advice

Adults: 50-100 mg, four times a day.

Prophylactic therapy: 50-100 mg, at night.

Children: 5-7 mg/kg/24 hours, given in divided doses, four times a day.

Use in pregnancy: Nitrofurantoin crosses the placenta and should be prescribed with caution in pregnant women, although studies have not shown a potential for birth defects.

Use in lactation: Small amounts of nitrofurantoin are excreted in breast milk, and the risk of haemolytic anaemia in neonates should be considered when prescribing to breastfeeding women.



Common side effects

  • Nausea
  • Loss of appetite

Uncommon side effects

  • Abdominal pain
  • Diarrhoea
  • Flatulence
  • Constipation
  • Headache
  • Dizziness
  • Drowsiness
  • Vertigo
  • Nystagmus
  • Confusion
  • Dermatitis
  • Rash
  • Itch
  • Transient alopecia
  • Asthma attacks in patients with a history of asthma.
  • Abnormalities in hepatic biochemistry and haematology laboratory values.

For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 1 January, 1970


Created by: myVMC