Ralodantin

Generic Name: Nitrofurantoin
Product Name: Ralodantin

Indication

Used for the treatment of urinary tract infections, including cystitis and pyelonephritis, caused by pathogens susceptible to Nitrofurantoin.

Action

Microbiology

Nitrofurantoin is a synthetic, nitrofuran derivative antibiotic. It is bacteriostatic at low concentrations and bactericidal at higher concentrations.

Nitrofurantoin has activity against common Gram negative and Gram positive urinary tract pathogens.

Pharmacokinetics

Nitrofurantoin is well absorbed from the gut, peak plasma levels are achieved within 1-2 hours. The plasma half life is 20 minutes. It is rapidly excreted in the urine, chiefly in the unchanged form.

Dose advice

Adults: 50-100 mg, four times a day.

Prophylactic therapy: 50-100 mg, at night.

Children: 5-7 mg/kg/24 hours, given in divided doses, four times a day.

Use in pregnancy: Nitrofurantoin crosses the placenta and should be prescribed with caution in pregnant women, although studies have not shown a potential for birth defects.

Use in lactation: Small amounts of nitrofurantoin are excreted in breast milk, and the risk of haemolytic anaemia in neonates should be considered when prescribing to breastfeeding women.