Generic Name: Lithium carbonate
Product Name: Quilonum SR
Prevention of manic or depressive episodes in bipolar disorder
Treatment of acute mania
Schizoaffective disorder and chronic schizophrenia
Augmentation for treatment-resistant depression
Unknown; actions include inhibition of dopamine release, enhancement of serotonin release and decrease formation of intracellular second messengers. Lithium has little or no psychotropic effect in normal individuals.
Maximum: 2500mg daily
Acute mania: Initially 750-1000mg daily. Measure serum concentration for 5-7 days and increase dose by 250-500mg daily (depending on serum concentration) until symptoms resolve. Check serum concentrations 5-7 days after each dose increase
Prophylaxis: 250-1000mg daily for 2 weeks, then adjust dose according to serum concentration
Elderly, renal impairment: use reduced dose and monitor carefully
Therapeutic range: Acute mania- 0.5-1.2mmol/L; Prophylaxis- 0.4-1.0mmol/L
Symptoms of toxicity: common > 1.5mmol/L (> 1.2mmol/L in the elderly) Clinical toxicity can occur at lower serum concentrations in some cases, particularly those with organic neurological damage or other CNS illnesses (e.g. epilepsy)
Continue maintenance treatment for 6-12 months after first episode of acute mania. Maintain prophylaxis if there is clear evidence for 2 or 3 episodes of either mania or depression in the last few years or if there is rapid cycling. Other factors, such as the severity of episodes and family history, may also suggest a need for ongoing prophylaxis.
Common side effects
Benign T wave changes on ECG
Uncommon side effects
Nephrogenic diabetes insipidus with polydipsia and polyuria
For further information talk to your doctor.