Placil

Generic Name: Clomipramine hydrochloride
Product Name: Placil

Indication

Obsessive-compulsive disorders
Major depression
Cataplexy associated with narcolepsy

Action

Tricyclic antidepressants (TCAâ??s) exert their effects by inhibiting reuptake of noradrenaline and serotonin into presynaptic terminals

Dose advice

25-75mg daily, increasing by 25-50mg every 2-3 days to 75-150mg daily. Maximum 300mg daily

Schedule

Common side effects

Sedation
Dry mouth
Blurred vision
Constipation
Weight gain
Orthostatic hypotension
Urinary hesitancy or retention
Reduced gastrointestinal motility
Anticholinergic delirium (particularly in the elderly and in Parkinsonâ??s Disease
Impotence
Loss of libido
Other sexual adverse effects
Tremor
Dizziness
Sweating
Agitation
Insomnia

Uncommon side effects

Slowed cardiac conduction
T wave inversion or flattening (particularly at high doses)
Arrhthmias
Sinus tachycardia
Nausea
Hyperglycaemia
Gynaecomastia in males
Breast enlargement and galactorrhoea in females
Allergic skin reactions
Manic episodes
Rare:
Blood dyscrasias
Hepatitis
Parlytic ileus
SIADH with hyponatraemia
Seizures