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Generic Name: Pancrelipase
Product Name: Pancrease


Used to replace pancreatic enzymes in patients who have insufficient amounts due to a number of reasons:
– cystic fibrosis
– chronic pancreatitis
– after having pancreas removed
– gastrointestinal bypass surgery
– obstruction of the pancreatic duct.


The body requires enzymes released by the pancreas in order to properly digest foods. Pancrease replaces these enzymes in the duodenum, the place they would usually be released, and normal digestion can take place. Proper digestion is important to ensure the body receives all the nutrients contained in food.

Dose advice

Dosage of Pancrease must be individualised to each patient and is determined based on symptoms and fat content of diet. Start with a low dose and adjust according to stool studies over three days.
Pancrease capsules should be taken with food and plenty of water should be drunk to maintain hydration. If swallowing of capsules is a problem, they can be opened and microspheres sprinkled on pH neutral food (banana, apricot, sweet potato, applesauce, instant pudding) and eaten immediately.
Enzyme activity is destroyed if Pancrease microspheres come in contact with anything with an alkaline pH (including stomach contents after antacid ingestion).
Recommended dosing regimes are as follows:
Adults and children
– 1-2 capsules with each meal
– 1 capsule with snacks
– individual variation may require higher dosing
– if doses higher than 3,125 BP lipase units/kg/meal are required, investigate for alternative cause of malabsorption
Infants < 12months
– contents of 1-2 capsules may be taken with food that does not require chewing



Common side effects

– nausea
– vomiting
– abdominal pain

Uncommon side effects

– diarrhoea
– abnormal stools
– constipation
– allergic or hypersensitivity reaction of the skin


For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 1 January, 1970

Created by: myVMC