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Generic Name: Codeine phosphate, Paracetamol
Product Name: Panadeine


Temporary relief of mild to moderate pain and fever.


Panadeine contains two active ingredients- paracetamol and codeine, which work in different ways to reduce pain. Paracetamol has painkilling as well as antipyretic (anti-fever) effects by preventing the production of chemical substances called prostaglandins, which are responsible for the pain and inflammatory response. Codeine is an opioid analgesic and works by activating opioid receptors in nervous system to produce painkilling effects. It also acts at the level of the spinal cord to prevent the transmission of pain impulses.

Dose advice

Each tablet of Panadeine contains 500 mg paracetamol and 8mg codeine phosphate.

  • Can be taken with or without food.


  • 1-2 tabs 4 hourly; max. 8 tabs daily



12’s, 24’s: S2

Other pack sizes: S3, except NSW: S2

Common side effects

As with any other medication, Panadeine can cause a number of side effects, most of which are likely to be minor and cease when the medication is stopped. Codeine phosphate is known to cause a number of side effects including:

  • Nausea and vomiting
  • Constipation (chronic use)
  • Dizziness
  • Dry mouth
  • Paracetamol is considered to have very few side effects when taken at normal doses.


Uncommon side effects

Less common side effects include:

  • hypersensitivity rashes
  • fever
  • blood abnormalities such as reduced numbers of white blood cells or platelets.


For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 1 January, 1970


Created by: myVMC