Oxetine

Generic Name: Paroxetine hydrochloride
Product Name: Oxetine

Indication

• Major depression
• Obsessive-compulsive disorder
• Panic disorder
• Generalised anxiety disorder
• Post-traumatic stress disorder
• Social phobia

Action

• Antidepressant action by selective inhibition of pre-synaptic uptake of serotonin (5- hydroxytryptamine, 5-HT), thus increasing the levels of this neurotransmitter in the brain.

Dose advice

Major depression:

• 20mg once daily, gradually increasing as necessary to a maximum of 50mg once daily. Use of maintenance doses of >20mg is not usually necessary.

Obsessive-compulsive disorder; social phobia; generalized anxiety disorder; Post-traumatic stress disorder:

• 20mg once daily, gradually increasing as necessary to a maximum of 50mg once daily.

Panic disorder:

• Start at 10mg daily, increasing if necessary to 10mg after a week to 20mg once daily. Use of maintenance doses >20mg is not routinely necessary.

Schedule

S4

Common side effects

• Nausea
• Agitation
• Insomnia
• Drowsiness
• Tremor
• Dry mouth
• Diarrhoea
• Dizzness
• Headache
• Sweating
• Asthenia
• Anxiety
• Weight gain or loss
• Sexual dysfunction
• Rhinitis
• Myalgia
• Rash

Uncommon side effects

• Extrapyramidal reactions (including Tardive Dyskinesia and dystonia)
• Sedation
• Confusion
• Palpitations
• Tachycardia
• Hypotension
• SIADH
• Abnormal platelet aggregation/ haemorrhagic complications (e.g. bruising, epistaxis, purpura)Rare:
• Elevated liver enzymes
• Hepatitis
• Hepatic failure
• Galactorrhoea
• Blood dyscrasias
• Seizures
• Akathesia

For further information talk to your doctor.