Orap

Generic Name: Pimozide
Product Name: Orap

Indication

• Treatment of acute and chronic psychoses.
• Tourette’s syndrome and other choreas.

Action

Blockade of dopaminergic transmission in various parts of the brain by antagonizing D2 receptors, which results in anti-psychotic effects, including relief from symptoms such as hallucinations, delusions or abnormal behaviour/thought.

Dose advice

• Adult: 2-12mg daily, maximum 20mg daily (use daily doses >12mg under specialist supervision only).

Child – Tourette’s syndrome:

• Initially 1-2mg daily, maximum 0.2mg/kg daily.

Schedule

S4

Common side effects

• Anticholinergic effects: dry mouth, blurred vision, constipation, tachycardia, urinary hesitancy, increased intraocular pressure, nausea and vomiting, sexual adverse effects.
• Orthostatic hypotension.
• Sedation.
• Extrapyramidal effects (Parkinsonism, Akathisia, Dystonias, Tardive dyskinesia).
• Hyperprolactinaemia (may result in galactorrhoea, gynaecomastia, amenorrhoea or infertility).

Uncommon side effects

• Allergic reactions
• Pigmentary changes of skin or eyes
• Corneal and lens opacities
• Hypothermia
• Hyperthermia
• SIADH

For further information talk to your doctor.