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Orap

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Generic Name: Pimozide
Product Name: Orap

Indication

Action

Blockade of dopaminergic transmission in various parts of the brain by antagonizing D2 receptors, which results in anti-psychotic effects, including relief from symptoms such as hallucinations, delusions or abnormal behaviour/thought.

Dose advice

  • Adult: 2-12mg daily, maximum 20mg daily (use daily doses >12mg under specialist supervision only).

Child – Tourette’s syndrome:

  • Initially 1-2mg daily, maximum 0.2mg/kg daily.

Schedule

S4

Common side effects

  • Anticholinergic effects: dry mouth, blurred vision, constipation, tachycardia, urinary hesitancy, increased intraocular pressure, nausea and vomiting, sexual adverse effects.
  • Orthostatic hypotension.
  • Sedation.
  • Extrapyramidal effects (Parkinsonism, Akathisia, Dystonias, Tardive dyskinesia).
  • Hyperprolactinaemia (may result in galactorrhoea, gynaecomastia, amenorrhoea or infertility).

Uncommon side effects

  • Allergic reactions
  • Pigmentary changes of skin or eyes
  • Corneal and lens opacities
  • Hypothermia
  • Hyperthermia
  • SIADH

For further information talk to your doctor.

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Dates

Posted On: 22 July, 2003
Modified On: 3 May, 2006

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Created by: myVMC