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Morphine Tartrate Injection (DBL)

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Generic Name: Morphine tartrate
Product Name: Morphine Tartrate Injection (DBL)

Indication

Morphine Tartrate Injection (DBL) is a powerful pain reliever used to treat severe, intractable pain in patients who are dying of cancer.

Action

Morphine is an opioid analgesic. Opioid analgesics work by mimicking the body¡¦s natural ¡§pain relief¡¨ chemicals, opioids. Morphine binds to receptors in the brain, spinal cord and other tissues (including intestinal smooth muscle) and stimulates these, thereby producing its pharmacological effects:
– pain relief
– decreased gastrointestinal motility (eg: constipation)
– reduced breathing
– cough suppression
– drowsiness
– contraction of pupils
– mood changes
– reduction in body temperature
In order to relieve pain directly, Morphine inhibits the release of the chemicals (neurotransmitters) that conduct pain, and also reduces the activity of the nerves that sense these chemicals.
The other effects of Morphine are controlled by activity in a variety of specific centres.

Dose advice

Morphine Tartrate Injection (DBL) can be administered subcutaneously, intramuscularly or intravenously. Facilities for resuscitation should be available wherever intravenous Morphine is being administered.
Adults
– 5-20mg subcutaneously or intramuscularly
– repeat every 4-6 hours
– intravenous administration may be used when a rapid onset of action is required
– 2.5-15mg should be diluted in 4-5ml water for injections and given slowly over 4-5 minutes
– dose increases should be made no more often than every 24 hours
Children
– 0.1-0.2mg/kg SC or IM
– repeat every 4-6 hours
– intravenous Morphine tartrate should be used with caution in children, titrating dose carefully
– 0.05-0.1mg/kg over 5-15 minutes
– there is no experience with repeat intravenous dosing in children
– Morphine tartrate is not usually used preoperatively in children under the age of 1
Continuous infusion
– after initial stabilisation, a continuous infusion can be used according to the patient¡¦s opioid use and analgesia requirements
– adults may be continued on 0.5-2.0mg/hr
Patient controlled analgesia (PCA)
– this may be appropriate in postoperative pain
– a continuous background infusion of 1mg/hr is used, with subsequent 0.5mg doses being controlled by the patient
– lockout intervals of 6-10 minutes are available
Cancer pain
– patients requiring opioid analgesia for cancer pain may require higher than recommended doses
– regular scheduling is thought to be of more benefit than ¡§on demand¡¨ dosing

Schedule

S8

Common side effects

The most common side effects seen with use of Morphine Tartrate Injection include:
– constipation (in virtually all patients on chronic treatment)
– lightheadedness
– dizziness
– sedation (usually clears within 3-5 days)
– nausea
– vomiting (can be treated with a suitable antiemetic agent)
– euphoria

Uncommon side effects

Other less common reactions include:
– confusion
– hallucinations
– delirium
– hives
– itch
– hypothermia
– decreased or increased heart rate
– raised intracranial pressure
– spasm of ureters or bile ducts
– muscle rigidity
– flushing

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For further information talk to your doctor.

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Dates

Posted On: 22 July, 2003
Modified On: 1 January, 1970


Created by: myVMC