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Methotrexate Injection and Tablets (DBL)

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Generic Name: Methotrexate
Product Name: Methotrexate Injection and Tablets (DBL)


Methotrexate is used in the treatment of moderate to severe rheumatoid arthritis. It is also used to treat a wide variety of other conditions including:



Methotrexate acts by suppressing the immune system and also destroys rapidly dividing cells (i.e. cancer cells). It also has an anti-inflammatory action.

Dose advice


  • The initial recommended dose is 7.5 mg given orally, intramuscularly or subcutaneously once each week for 6 weeks.
  • Maintenance dosing is 5-25 mg given once a week.

Children: 5-15 mg per square metre of body surface area given orally, intramuscularly or subcutaneously once each week.

Kidney function impairment: The dose of methotrexate should be reduced depending on the degree of kidney function impairment.

Liver function impairment: If liver enzymes are markedly elevated the use of Methotrexate may be contraindicated in conditions such as psoriasis, rheumatoid arthritis, severe asthma and inflammatory bowel disease.

Pregnancy: Methotrexate should be avoided in pregnancy unless its benefits outweigh the risks and it should be avoided during breastfeeding.




Common side effects


  • Bone marrow suppression.
  • Nausea.
  • Vomiting.
  • Increased sensitivity to light.


Uncommon side effects



For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 31 October, 2015


Created by: myVMC