Melleril

Generic Name: Thioridazine; Thioridazine hydrochloride
Product Name: Melleril

Indication

Melleril is used to treat psychotic disorders unresponsive to at least 2 other antipsychotics.

Action

Antagonise D2 receptors resulting in anti-psychotic effects, including relief from symptoms such as hallucinations, delusions or abnormal behaviour/thought.

Dose advice

Adult:

• 50-600mg daily in 3 divided doses. Maximum 800mg daily for up to 4 weeks.

Schedule

S4

Common side effects

• Anticholinergic effects: dry mouth, blurred vision, constipation, tachycardia, urinary hesitancy, increased intraocular pressure, nausea, sexual adverse effects.
• Orthostatic hypotension
• Sedation
• Extrapyramidal effects (Parkinsonism, Akathisia, Dystonias, Tardive Dyskinesia)
• Hyperprolactinaemia (may result in galactorrhoea, gynaecomastia, amenorrhoea or infertility)

Uncommon side effects

• Allergic reactions
• Pigmentary changes of skin or eyes
• Corneal and lens opacities
• Hypothermia
• Hyperthermia
• SIADH

For further information talk to your doctor.