Generic Name: Fluvoxamine maleate
Product Name: Luvox
Obsessive-compulsive disorder, including children
Antidepressant action by selective inhibition of pre-synaptic uptake of serotonin (5- hydroxytryptamine, 5-HT)
Fluvoxamine inhibits liver cytochrome enzymes, CYP1A2 and CYP3A4, responsible for the metabolism of many other drugs, thus potentially interacting with those drugs by decreasing their metabolism
Initially 50mg once daily, gradually increasing as necessary to 100-300mg daily.
In depression, doses > 100mg daily are not usually needed.
Give doses > 150mg in 2 divided doses
Maximum 300mg daily
Children > 8 years:
25mg once daily, increasing every 4-7 days as tolerated to a maximum of 200mg
Give doses > 50mg daily in 2 divided doses
Common side effects
â?¢ Dry mouth
â?¢ Weight gain or loss
â?¢ Sexual dysfunction
Uncommon side effects
Extrapyramidal reactions (including tartive dyskinesia and dystonia)
Abnormal platelet aggregation/ haemorrhagic complications (e.g. bruising, epistaxis, purpura)
Elevated liver enzymes
â?¢ Blood dyscrasias
For further information talk to your doctor.