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Kredex

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Generic Name: Carvedilol
Product Name: Kredex

Indication

Kredex is used in the treatment of high blood pressure. It is also used in conjunction with other agents in the treatment of mild to severe congestive heart failure (CHF).

Action

Carvedilol is from the family of drugs known as beta-blockers. It blocks receptors in the heart, causing it to slow down. Carvedilol also has activity on other receptors known as alpha-receptors, which are found on blood vessels. It is via alpha-receptor blockade that it reduces blood pressure.

Dose advice

Hypertension:

  • once daily dosing is recommended

Adults

  • 12.5mg daily for the first two days
  • 25mg daily thereafter
  • if needed, dosage may be increased at two week intervals to a maximum of 50mg/day
  • 50mg can be given as one dose or divided doses

Elderly

  • 12.5mg daily initially
  • if response is inadequate dose can be increased at two weekly intervals to a maximum of 50mg/day
  • An alternative to increasing dose is to combine Carvedilol with other antihypertensive agents such as diuretics.

Symptomatic congestive heart failure (CHF):

  • dose must be individualised and closely monitored by doctor during up-titration
  • doses of all other cardiac medications should be stabilised before initiating Carvedilol
  • starting dose is 3.125mg twice daily for two weeks
  • if this dose is tolerated, increase at two-weekly intervals to 6.25mg twice daily then 12.5mg, then 25mg
  • in patients less than 85kg, 25mg twice daily is the maximum recommended dosage
  • patients heavier than 85kg may have their dose increased to 50mg twice daily
  • all patients with severe CHF should have no more than 25mg twice daily
  • before each dose increase patients should be evaluated for worsening heart failure, vasodilation and bradycardia
  • if side effects occur, it may be necessary to reduce the dose or even stop Carvedilol temporarily
  • if it is stopped for longer than two weeks, therapy should be restarted at 3.125mg and titrated as before
  • dosage adjustments are not required for patients with renal failure, however close observation and caution are necessary in these patients

Schedule

S4

Common side effects

Side effects that occurred in greater than 2% of patients include:

  • fatigue
  • chest pain
  • pain
  • slow heart rate
  • low blood pressure
  • dizziness
  • headache
  • diarrhoea
  • nausea
  • abdominal pain
  • vomiting
  • increased blood sugar level
  • weight gain
  • gout
  • back pain
  • joint aches
  • upper respiratory tract infection

Uncommon side effects

Side effects that occurred less commonly included:

  • swelling of extremities
  • allergy
  • malaise
  • postural hypotension (feeling lightheaded on standing)
  • vertigo
  • black stools
  • oversleeping
  • impotence
  • low blood sugar level

For further information talk to your doctor.

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Dates

Posted On: 22 July, 2003
Modified On: 19 March, 2016


Created by: myVMC