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DBL Glyceryl Trinitrate for Injection

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Generic Name: Glyceryl trinitrate
Product Name: DBL Glyceryl Trinitrate for Injection

Indication: What DBL Glyceryl Trinitrate for Injection is used for

Glyceryl trinitrate belongs to a group of medicines called nitrates or vasodilators. It relaxes the muscles surrounding blood vessels (arteries and veins) and so helps more blood and oxygen reach the heart. It is also used to control or lower the blood pressure during some surgical procedures.

Your doctor may have prescribed glyceryl trinitrate for another reason. Ask your doctor if you have any questions about why glyceryl trinitrate has been prescribed for you.

Glyceryl trinitrate is not addictive.

This medicine is available only with a doctor’s prescription.

Glyceryl trinitrate is not recommended for use in children, as there is not enough information on its effects in children.

Action: How DBL Glyceryl Trinitrate for Injection works

Glyceryl trinitrate produces a dose-related dilation of both arterial and venous beds. Venous dilation predominates over-dilation of the arterioles. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (pre-load). Arteriolar relaxation reduces systemic vascular resistance and arterial pressure (after-load). Glyceryl trinitrate also dilates the coronary arteries, although this effect is short-lived.

DBL Glyceryl Trinitrate for Injection contains 50mg/10mL of the active ingredient glyceryl trinitrate.

It also contains the inactive ingredients ethanol, propylene glycol, and water for injections.

DBL Glyceryl Trinitrate for Injection does not contain lactose, sucrose, gluten, tartrazine or any other azo dyes.

Dose advice: How to use DBL Glyceryl Trinitrate for Injection

Before you are given DBL Glyceryl Trinitrate for Injection

When you must not be given it

You should not be given DBL Glyceryl Trinitrate for Injection if you have an allergy to glyceryl trinitrate or any of the ingredients listed here. Symptoms of an allergic reaction to glyceryl trinitrate may include:

  • Shortness of breath, wheezing or difficulty breathing;
  • Swelling of the face, lips, tongue or other parts of the body;
  • Rash, itching or hives on the skin.

You should not be given glyceryl trinitrate if you have any of the following conditions:

  • Low blood pressure;
  • A recent head injury or stroke;
  • Swelling around the heart;
  • Reduced red blood cells and iron stores (anaemia) or a lack of oxygen in the blood;
  • An abnormality of haemoglobin, part of your red blood cells, responsible for carrying oxygen.

If you are not sure whether you should be given DBL Glyceryl Trinitrate for Injection, talk to your doctor or pharmacist.

Before you are given it

Tell your doctor or pharmacist if you have allergies to:

  • Any other medicines;
  • Any other substances, such as foods, preservatives or dyes.

Tell your doctor or pharmacist if you are pregnant or intend to become pregnant. Like most vasodilator medicines, glyceryl trinitrate is not recommended for use during pregnancy. If there is a need to consider glyceryl trinitrate during your pregnancy, your doctor or pharmacist will discuss with you the benefits and risks of using it.

Tell your doctor or pharmacist if you are breastfeeding or intend to breastfeed. Like most vasodilator medicines, glyceryl trinitrate is not recommended while you are breastfeeding. It is not known if glyceryl trinitrate is excreted into breastmilk.

Tell your doctor or pharmacist if you have or have had any medical conditions, especially the following:

  • Liver disease;
  • Kidney disease;
  • A recent heart attack or any heart condition for which you already use a nitrate vasodilator drug such as Anginine or patches or sprays containing a nitrate;
  • Heart disease caused by poor blood flow in the arteries of the heart;
  • Any other heart condition;
  • Any lung condition.

If you have not told your doctor or pharmacist about any of the above, tell them before you are given DBL Glyceryl Trinitrate for Injection.

Taking other medicines

Tell your doctor or pharmacist if you are taking or using any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and glyceryl trinitrate may interfere with each other. These include:

  • Alcohol;
  • Aspirin and other nonsteroidal anti-inflammatory medicines (NSAIDs);
  • Morphine, a medicine used for pain;
  • Some medicines for depression such as tricyclic antidepressants;
  • Some medicines that block nerve conduction to muscles such as anticholinergics;
  • Heparin, a medicine used to prevent blood clots;
  • Some medicines used to treat high blood pressure;
  • Ergotamine, methysergide and dihydroergotamine; medicines used to prevent or treat migraine headaches;
  • Tranquillisers, medicines used to treat some mental illnesses;
  • Viagra (sildenafil), a medicine for impotence.

These medicines may be affected by glyceryl trinitrate or may affect how well it works. You may need different amounts of your medicine, or you may need to take or use different medicines. Your doctor or pharmacist will advise you.

Your doctor and pharmacist may have more information on medicines to be careful with or avoid while you are being given glyceryl trinitrate.

How DBL Glyceryl Trinitrate for Injection is given

DBL Glyceryl Trinitrate for Injection is always diluted before use. It should not be mixed with other drugs.

How much is given

Due to variations in the response of individual patients to the drug, the dose of glyceryl trinitrate varies. Your doctor will decide what dose you will receive. This depends on your condition and other factors, such as your weight.

How it is given

DBL Glyceryl Trinitrate for Injection is usually diluted and given as a slow infusion or ‘drip’ injection into your veins (intravenously).

If you receive too much (overdose)

As DBL Glyceryl Trinitrate for Injection is most likely to be given to you in hospital under the supervision of your doctor, it is very unlikely that you will receive too much. However, if you experience severe side effects tell your doctor immediately.

Symptoms of a glyceryl trinitrate overdose include the side effects listed in the ‘Side Effects’ section but are usually of a more severe nature.

Ask your doctor or pharmacist if you have any concerns.

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much glyceryl trinitrate. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

While you are being given DBL Glyceryl Trinitrate for Injection

Things to be careful of

Be careful driving or operating machinery until you know how glyceryl trinitrate you. As with other vasodilator medicines, glyceryl trinitrate may cause dizziness, lightheadedness, fainting and headache in some people. Make sure you know how you react to glyceryl trinitrate before you drive a car, operate machinery, or do anything else that could be dangerous if you are dizzy or light-headed. If this occurs do not drive.

If you drink alcohol, dizziness or light-headedness may be worse.

After using DBL Glyceryl Trinitrate for Injection

Storage

DBL Glyceryl Trinitrate for Injection will be stored in the pharmacy or on the ward. The injection is kept in a cool dry place, protected from light, where the temperature stays below 25°C.

Schedule of Glyceryl Trinitrate for Injection (DBL)

DBL Glyceryl Trinitrate for Injection is a Schedule 4 (prescription only) medicine.

Side effects of DBL Glyceryl Trinitrate for Injection

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are being given glyceryl trinitrate. Glyceryl trinitrate helps most people with blood pressure problems or heart pain, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

Do not be alarmed by the following list of possible side effects. You may not experience any of them.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

These are the more common side effects of glyceryl trinitrate. Mostly these are short-lived.

Tell your doctor or pharmacist if you notice any of the following:

These are the less common side effects.

Other side effects not listed above may occur in some patients. Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

For further information talk to your doctor.

References

  1. DBL Glyceryl Trinitrate for Injection Consumer Medicine Information (CMI). Melbourne VIC: Hospira Australia Pty Ltd. November 2011. [PDF]
  2. DBL Glyceryl Trinitrate for Injection Product Information (PI). Melbourne VIC: Hospira Australia Pty Ltd. December 2016. [PDF]
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Dates

Posted On: 22 July, 2003
Modified On: 3 April, 2018
Reviewed On: 3 April, 2018

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Created by: myVMC