GenRx Metoprolol

Generic Name: Metoprolol tartrate
Product Name: GenRx Metoprolol

Indication

GenRx Metoprolol is used for:

• Hypertension
• Angina
• Tachyarrhythmias
• Myocardial Infarction
• Prevention of migraine

Action

• Atenolol, a type of beta-1-selective-beta-Blocker, competitively blocks beta- adrenoceptors in the heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
• The antihypertensive effect works by reducing cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretionmay also contribute.
• The antianginal effect is due to reductionin left ventricular work and oxygen use, resulting from decrease in heart rate and contractility. The antiarrhythmic properties are due to antisympathetic effects: depression of sinus node function and atrio-ventricular conduction and prolongation of atrial refractory periods.
• Atenolol, a beta-1-selective blocker, has a higher affinity for beta-1 receptors in the heart with less effect on beta-2 receptorsin bronchi and peripheral vasculature.

Dose advice

Hypertension:

• Oral: initially 50-100mg once daily for 1 Week; maintenance 50-100mg once or twice daily.

Angina:

• Oral: initially 25-50mg twice daily; maintenance 50-100mg 2-3 times daily.

Tachyarrhthmias:

• Oral: 50-100mg 2-3 times dailyIV: 5mg (1mg/minute), repeated at 5 Minute intervals up to a maximum of 20mg

Myocardial Infarction:

• Initially, IV 5mg at 5 minute intervals to a total of 15mg, then 25-50mg orally every 6 hours for 48 hours.

Prevention of migraine:

• Oral: 50-75mg twice daily.

Schedule

S4

Common side effects

• Nausea
• Diarrhoea
• Bronchospasm
• Dyspnoea
• Cold extremities
• Exacerbation of Raynaud’s phenomenon
• Bradycardia
• Hypotension
• Heart failure
• Heart block
• Fatigue
• Dizziness
• Abnormal vision
• Decreased concentration
• Hallucinations
• Insomnia
• Nightmares
• Depression
• Altered glucose and lipid metabolism

Uncommon side effects

• Rash
• Exacerbation of psoriasis
• Impotence
• Muscle cramp
• Acute urinary retention
• Nasal congestion
• Hypersensitivity reaction
• Thrombocytopenic purpura
• Liver function abnormality
• Alopecia
• Cardiac arrest
• Hepatic injury

For further information talk to your doctor.