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Generic Name: Piperazine oestrone sulfate
Product Name: Genoral


Genoral is a hormone replacement therapy used in women who suffer from a deficiency in oestrogen.


Genoral contains a drug that acts like oestrogen, and thus can help correct symptoms in oestrogen-deficient women.

Dose advice

Genoral is usually taken daily in a dose ranging from 0.625mg to 7.5mg.

If you still have an intact uterus, you should also be on a medication that prevents overgrowth of your uterus while on Genoral.

Your doctor may increase or decrease your dose depending on your clinical response. The need for Genoral should be re-evaluated every six months due to the potential adverse effects of long-term use.

Genoral should not be taken during pregnancy (ADEC Pregnancy Category D).

Its effects in breastfeeding mothers and their children have not been studied, and is therefore not recommended.


Schedule 4

Common side effects

Very common side effects experience by more than 10% of patients using Genoral include:

The following side effects occur commonly (<10% but >1% of patients). Do not be alarmed by the list. If you experience any of the adverse effects listed and are concerned about them, see your doctor.

  • Bigger breasts, breast discomfort
  • Acne
  • Itching and rashes
  • Hair abnormalities
  • Increased sweating
  • Dizziness
  • Moods
  • Nervousness
  • Abdominal pain and cramps
  • Flatulence and bloating, constipation or diarrhoea
  • Nausea
  • Changes in menstrual flow
  • Thrush
  • Problems sleeping
  • High blood pressure
  • Reduced carbohydrate tolerance
  • Reduced glucose tolerance

Uncommon side effects

Uncommon side effects occur in less than 1% of patients taking Genoral:

  • Allergic reactions
  • Stroke
  • Clot in the veins
  • Breast cancer
  • Cardiovascular events
  • Inflammation of the gallbladder
  • Gallstones

Consult your doctor if you experience any of the above symptoms, or any other unusual or abnormal symptoms that concern you.


  1. MIMS online [online]. 2003 [cited 2007 December 3]. Available from: [URL Link]
  2. Australian Medicines Handbook, Adelaide, Pharmaceutical Society of Australia, 2007.

For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 1 February, 2008
Reviewed On: 16 January, 2008


Created by: myVMC