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Generic Name: amitriptyline hydrochloride
Product Name: Endep

Indication: What Endep is used for

Endep is used to treat depression. Endep 10 mg and Endep 25 mg tablets can be used at any stage in the treatment of depression. However, the highest strength Endep 50 mg, is approved only for the maintenance treatment of depression (after your symptoms have improved).

Endep can also be used to treat bed-wetting, provided that there is no physical cause for the problem (e.g. problems with the bladder).

Ask your doctor if you have any questions about why Endep has been prescribed for you. Your doctor may have prescribed Endep for another reason.

Endep is not approved for use in children and adolescents below 18 years of age for the treatment of depression. The safe use and effectiveness of Endep in treating depression for this age group has not been established.

Endep is available only with a doctor’s prescription.

Action: How Endep works

Endep belongs to a group of medicines called tricyclic antidepressants (TCAs). TCA medicines work by correcting the imbalance of certain chemicals in the brain. These chemicals, called amines, are involved in controlling mood. By correcting this imbalance, TCAs can help relieve the symptoms of depression.

The active ingredient in Endep is amitriptyline hydrochloride. Each Endep tablet contains 10 mg, 25 mg or 50 mg of amitriptyline hydrochloride.

Endep tablets also contain the inactive ingredients lactose, microcrystalline cellulose, disodium edetate, sodium starch glycollate, pregelatinised maize starch, colloidal anhydrous silica, magnesium stearate, purified talc [10 mg and 50 mg only], Opadry Blue OY-B-30904 (includes colours 133, 171) [10 mg only], Opadry Yellow OY-LS-32814 (includes colours 104, 110, 132, 171) [25 mg only], Opadry Buff OY-LS-37200 (includes colours 171, 172) [50 mg only].

Endep tablets are gluten free.

Dose advice: How to use Endep

Before you take Endep

When you must not take it

Do not take Endep if you are allergic to medicines containing amitriptyline (e.g. Tryptanol) or any of the ingredients listed here. Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face or tongue which may cause difficulty swallowing or breathing; increased the sensitivity of the skin to the sun.

Do not take Endep if you have recently had a heart attack. Taking Endep could make your condition worse.

Do not take Endep if you are taking, or have taken within the last 14 days another medicine for depression called a monoamine oxidase inhibitor (MAOI). Taking Endep with a MAOI or taking it too soon after stopping a MAOI may cause a serious reaction with a sudden increase in body temperature, extremely high blood pressure and severe convulsions. Your doctor will tell you when it is safe to start taking Endep after stopping the MAOI.

Ask your doctor or pharmacist if you are unsure if you are taking, or have been taking a MAOI. MAOIs are medicines used to treat depression and symptoms of Parkinson’s disease. Examples of MAOIs are phenelzine (Nardil), tranylcypromine (Parnate), moclobemide (eg. Aurorix, Arima) and selegiline (Eldepryl, Selgene).

Do not take Endep if you are taking cisapride (Prepulsid), a medicine used to treat stomach reflux. Combining Endep with cisapride may cause serious side effects such as an abnormal heart rhythm.

Do not take Endep if you are breastfeeding. Endep passes into breast milk and may harm your baby.

Do not take Endep if the expiry date (EXP) printed on the pack has passed. If you take this medicine after the expiry date has passed, it may not work as well.

Do not take Endep if the packaging shows signs of tampering or the tablets do not look quite right.

If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you start to take it

Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.

Tell your doctor if you are pregnant or plan to become pregnant. There have been reports of some babies experiencing complications immediately after delivery. Your doctor will discuss the possible risks and benefits of taking Endep during pregnancy.

Tell your doctor if you have, or have had, any other medical conditions, especially the following:

  • Heart or blood vessel problems;
  • Liver problems;
  • Glaucoma, a condition characterised by an increased pressure in the eye;
  • Urinary problems such as difficulty in passing urine;
  • Thyroid problems;
  • Seizures or fits;
  • Any mental illness other than depression, for example, schizophrenia.

Tell your doctor if you plan to undergo any type of surgery or if you are undergoing electroshock therapy.

If you have not told your doctor about any of the above, tell him/her before you start taking Endep.

Taking other medicines

Do not take Endep if you are taking:

  • Cisapride (Prepulsid), a medicine used to treat stomach reflux;
  • Any monoamine oxidase inhibitor (MAOI) such as:
    • Phenelzine (Nardil) and tranylcypromine (Parnate), moclobemide (e.g. Aurorix, Arima), used to treat depression;
    • Selegiline (Eldepryl, Selgene), used to treat symptoms of Parkinson’s disease;

Wait at least 14 days after stopping your MAOI before starting Endep.

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines may be affected by Endep or may affect how well Endep works. These include:

  • Selective serotonin reuptake inhibitors (SSRIs), a group of medicines used to treat depression and other mental illnesses, such as fluoxetine (e.g. Prozac, Lovan), sertraline (e.g. Zoloft) and paroxetine (e.g. Aropax, Paxtine);
  • Some medicines used to treat high blood pressure;
  • Anticholinergics, found in some medicines used to relieve stomach cramps; travel sickness; hayfever and allergies; a cough and colds;
  • Medicines used to treat mental disorders such as schizophrenia;
  • Quinidine (Kinidin) and flecainide (Tambocor, Flecatab), medicines used to control an irregular heartbeat;
  • Cimetidine (e.g. Tagamet, Magicul), a medicine used to treat reflux and ulcers;
  • Sleeping tablets/sedatives, anti-anxiety medicines;
  • Medicines for epilepsy;
  • Thyroid medicines;
  • Disulfiram (e.g. Antabuse), a medicine used to deter alcohol consumption;
  • Tramadol (e.g. Tramal), a medicine used to relieve pain.

Your doctor can tell you what to do if you are taking any of these medicines. If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Endep.

How to take Endep

Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained here.

If you do not understand the instructions on the pack, ask your doctor or pharmacist.

How much to take

The dose varies from person to person. Your doctor will decide the right dose for you.


Endep is usually started at a low dose and then, if necessary, increased depending on how your symptoms improve and how well you tolerate it. For depression, the usual starting dose is 75 mg to 150 mg per day in divided doses.

For people being treated in hospital for their depression, the usual starting dose is 100 mg to 200 mg per day.

For the elderly, lower doses are recommended, as Endep may not be well tolerated in this age group.

Your doctor may then reduce your dose to 50 mg to 100 mg per day when your depressive symptoms have improved, depending on your response to Endep.


Keep Endep out of the reach of children.

Do not give your child more Endep than what is recommended by your doctor. The doses recommended for bed-wetting are lower than the doses used to treat depression and usually depend on the person’s age and weight.

How to take it

Swallow the tablets whole with a glass of water.

When to take it

Endep can be taken with or without food.

Endep can be taken as a single dose (e.g. at bedtime) or as divided doses (e.g. three times a day). Your doctor will advise you.

Take your medicine at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it.

How long to take it for


Keep taking Endep for as long as your doctor recommends. The length of treatment will depend on how quickly your symptoms improve.

Most medicines for depression take time to work, so do not be discouraged if you do not feel better right away. Some people notice an improvement in their depressive symptoms after 3 or 4 days. However, it may take up to 4 weeks to feel the full benefits of Endep.

Even when you feel well, your doctor may ask you to continue taking Endep for 3 months or longer to make sure that the benefits last.


Most children respond to treatment in the first few days. However, continued treatment is usually required to maintain the response until bed-wetting ends.

If you forget to take it

If you take one dose a day (at bedtime)

If you forget to take Endep before going to bed and wake up late in the night or early in the morning, do not take the missed dose until you have checked with your doctor.

You may have difficulty waking up or experience drowsiness in the morning or during the day if you take Endep at these times.

If you take more than one dose a day

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take the missed dose as soon as you remember, and then go back to taking your tablets as you would normally.

Do not try to make up the dose you missed by taking a double dose.

If you are not sure what to do, ask your doctor or pharmacist.

If you have trouble remembering to take your tablets, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Endep. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

If you take too much Endep, you may feel drowsy, cold, very dizzy or have a fast or irregular heartbeat. You may also have fits, difficulty breathing or lose consciousness.

Keep Endep out of the reach of children. Children are much more sensitive than adults to medicines such as Endep. An accidental overdose is especially dangerous in children.

While you are taking Endep

Things you must do

Tell your doctor immediately if you have any suicidal thoughts or other mental/mood changes. Occasionally, the symptoms of depression or other psychiatric conditions may include thoughts of harming yourself or committing suicide. These symptoms may continue or get worse during the first one to two months of treatment until the full antidepressant effect of the medicine becomes apparent. This is more likely to occur in children, adolescents and young adults under 25 years of age.

Contact your doctor or a mental health professional right away or go to the nearest hospital for treatment if you or someone you know is showing any of the following warning signs of suicide:

  • Worsening of your depression;
  • Thoughts or talk of death or suicide;
  • Thoughts or talk of self-harm or harm to others;
  • Any recent attempts of self-harm;
  • Increase in aggressive behaviour, irritability or any other unusual changes in behaviour or mood.

All mentions of suicide or violence must be taken seriously.

Tell your doctor if you feel the tablets are not helping your condition.

Keep all of your appointments with your doctor so that your progress can be checked.

Tell your doctor immediately if you become pregnant while taking Endep. Do not stop taking your tablets until you have spoken to your doctor.

Before starting any new medicine, tell your doctor or pharmacist that you are taking Endep.

Tell all the doctors, dentists and pharmacists who are treating you that you are taking Endep.

If you plan to have surgery, including dental surgery, tell your doctor or dentist that you are taking Endep. Your doctor may ask you to temporarily stop taking Endep a few days before elective surgery.

Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily.

Things you must not do

Do not drive or operate machinery until you know how Endep affects you. Endep may reduce your alertness, cause drowsiness or dizziness in some people. If you experience any of these symptoms, do not drive, operate machinery or do anything else that could be dangerous.

For the same reasons, children should not ride a bike, climb trees or do anything else that could be dangerous if they are drowsy.

Do not stop taking Endep, or lower the dose, without checking with your doctor. Do not let yourself run out of your medicine over weekends or during holidays. Stopping Endep suddenly may make you feel sick (nauseous), have headaches or feel generally unwell. Your doctor will tell you how to gradually reduce the amount of Endep you are taking before stopping completely.

Do not use Endep to treat any other conditions unless your doctor tells you to.

Do not give Endep to anyone else, even if they have the same condition as you.

Things to be careful of

Be careful drinking alcohol while taking Endep. Combining Endep with alcohol can make you more drowsy or dizzy. Your doctor may suggest you avoid alcohol while being treated for depression.

Be careful getting up from a sitting or lying position. Dizziness, lightheadedness or fainting may occur, especially when you get up quickly. Getting up slowly may help.

Tell your doctor or dentist if your mouth continues to feel dry for more than 2 weeks. Endep may cause dry mouth. This can be relieved by frequent sips of water, sucking sugarless lollies or chewing sugarless gum. However, continuing dryness of the mouth may increase the chance of dental disease, including tooth decay and gum disease.

After taking Endep


Keep Endep where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Keep your tablets in a cool dry place where the temperature stays below 30 degrees C. Do not store Endep or any other medicine in the bathroom or near a sink. Do not leave Endep in the car or on window sills. Heat and dampness can destroy some medicines.


If your doctor tells you to stop taking Endep, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.

Schedule of Endep

Endep is an S4 (prescription only) medicine.

Side effects of Endep

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Endep. Endep helps most people, but it may have unwanted side effects in some people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:

The above list includes the milder side effects of Endep.

Tell your doctor as soon as possible if you notice any of the following:

  • Fast or irregular heartbeats;
  • Larger breast than normal (in men and women);
  • Tingling or numbness of the hands or feet;
  • Uncontrolled movements, including trembling and shaking of the hands and fingers, twisting movements of the body, shuffling walk and stiffness of the arms and legs;
  • Difficulty in passing urine;
  • Signs of frequent infections such as fever, chills, sore throat or mouth ulcers;
  • Yellowing of the eyes or skin (jaundice);
  • Unusual bruising or bleeding;
  • Feeling anxious, restless or confused;
  • Abnormal ideas, hallucinations;
  • Sudden switch of mood to one of excitement, overactivity, talkativeness and uninhibited behaviour.

The above side effects are serious and may require medical attention.

Tell your doctor immediately or go to Accident and Emergency at the nearest hospital if you notice any of the following:

  • Skin rash, itching, hives; swelling of the face or tongue; severe sunburn, blistering or swelling of the skin;
  • Fainting or collapse;
  • Chest pain;
  • Seizures or fits.

The above side effects are very serious and may require urgent medical attention or even hospitalisation.

Tell your doctor if you notice anything that is making you feel unwell. Other side effects not listed above may also occur in some people.

For further information talk to your doctor.


  1. Endep Consumer Medicine Information (CMI). Glebe, NSW: Alphapharm Pty Limited. May 2008. [PDF]
  2. Endep Product Information (PI). Glebe, NSW: Alphapharm Pty Limited. December 2012. [PDF]
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Posted On: 22 July, 2003
Modified On: 15 March, 2018
Reviewed On: 15 March, 2018


Created by: myVMC