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Generic Name: Amitriptyline hydrochloride
Product Name: Endep


Endep is used for:

  • Major depression.
  • Bed-wetting, urge incontinence.
  • Adjunct in pain management.



Tricyclic antidepressants (TCA’s) exert their effects by inhibiting the re-uptake of noradrenaline and serotonin into presynaptic terminals.

Dose advice

Depression in adults:

  • 25-75mg daily, increasing by 25-50mg every 2-3 days to 75-150mg daily. Maximum 300mg daily.


Urinary urge incontinence:

  • 10-25mg 1-3 times daily.


Nocturnal enuresis in children:

  • Child 7-10 years- 10-20mg 30-60 minutes before bedtime; maximum period of treatment is 3 months.
  • Child older than 10 years- 25-50mg 30-60 minutes before bedtime; maximum period of treatment is 3 months.
  • Do not use for enuresis (Involuntary urination) in children under 7 years.




Common side effects

See uncommon side effects.

Uncommon side effects


  • Sedation.
  • Dry mouth.
  • Blurred vision.
  • Constipation.
  • Weight gain.
  • Orthostatic hypotension.
  • Urinary hesitancy or retention.
  • Reduced gastrointestinal motility.
  • Anticholinergic delirium (particularly in the elderly and in Parkinson’s Disease.
  • Impotence.
  • Loss of libido.
  • Other sexual adverse effects.
  • Tremor.
  • Dizziness.
  • Sweating.
  • Agitation.
  • Insomnia.


For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 1 January, 1970


Created by: myVMC