Generic Name: Diazepam
Product Name: Diazepam Injection (DBL)
- Short term management of anxiety
- Acute alcohol withdrawal
- Acute benzodiazepine withdrawal
- Muscle spasm
- Conscious sedation
- Status epilepticus
- Parasomnias (night terrors; sleep walking)
Benzodiazepines potentiate the inhibitory effects of gamma aminobutyric acid (GABA throughout the CNS, resulting in anxiolytic, sedative hypnotic, muscle relaxant and antiepileptic effects).
1-10mg up to 3 times a day. Additional doses are sometimes needed.
- Premedication: 0.1-0.2mg/kg IV
- Acute severe anxiety, muscle spasm: 5-10mg IV repeated in 3-4 hours if necessary
- Acute benzodiazepine withdrawal: give divided doses of diazepam equivalent to the patientÂ?s daily benzodiazepine consumption; if this is not known, give oral diazepam 20mg every 2 hours until withdrawal symptoms are controlled; gradually taper dosage over subsequent days
- Elderly and/or debilitated patient: 2mg orally twice daily
- Premedication: rectal/oral 0.2-0.4mg/kg
- Muscle spasm, anxiety: IV 0.1-0.3mg/kg every 1-4 hours, up to 0.6mg/kg in 8 hours. Oral 0.05-0.3mg/kg 2-3 times daily
- Give IV no faster than 5mg/minute.
- Avoid extravasation and intra-arterial injection.
- Avoid IM administration, particularly as emulsion formulation of injection has been discontinued.
- Avoid dilution and infusion of injection as diazepam has low solubility and adsorbs to PVC giving sets.
Common side effects
- Memory loss
- Slurred speech
Uncommon side effects
- Paradoxical excitation
- Aggression and hostility
- Decreased libido
- Anterograde amnesia
- Pain and thrombophlebitis with IV injection
- Respiratory arrest with IV use
For further information talk to your doctor.