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Dantrium for Injection

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Generic Name: dantrolene sodium
Product Name: Dantrium

Indication: What Dantrium is used for

Dantrium for injection is a muscle relaxant used to treat a condition known as malignant hyperthermia. This condition occurs rarely during or after surgery or anaesthesia. The tendency to develop malignant hyperthermia may be inherited.

Some of the symptoms of malignant hyperthermia are very high fever, fast and irregular heartbeat, difficulty breathing and rigid muscles. Malignant hyperthemia may be fatal if not treated.

Your doctor may have prescribed Dantrium for injection for a purpose other than that listed above. Ask your doctor if you have any questions about why Dantrium was prescribed for you.

Action: How Dantrium Powder for Injection works

Dantrolene sodium is a muscle relaxant acting specifically on skeletal muscle. It does not affect neuromuscular transmission nor does it have measurable effects on the electrically excitable surface membrane. Studies have shown that in the presence of dantrolene sodium, the responses of the muscle to caffeine are decreased or delayed. In isolated muscle preparations, dantrolene sodium uncouples the excitation and contraction of skeletal muscle, probably by interfering with the release of calcium from the sarcoplasmic reticulum.

Dantrium powder for injection contains 20 milligrams of dantrolene sodium. It also contains mannitol and sodium hydroxide.

Dose advice: How to use Dantrium

Treatment with Dantrium

How Dantrium is given

Dantrium will be given to you by your doctor as soon as malignant hyperthermia is recognised. It will be given by injection into a vein. Treatment must continue until all symptoms of malignant hyperthermia are gone.

The starting dose of Dantrium is calculated by your doctor according to your body weight. The recommended starting dose is 1 milligram per kilogram of body weight (1 mg/kg).

More Dantrium will be given by your doctor until all symptoms of malignant hyperthermia are gone. The highest recommended dose is 10 mg/kg.

Treatment may be repeated if symptoms return after initial recovery.

Ask your doctor if you have any questions about your treatment.

If you are given too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency (Casualty) at your nearest hospital if you think that you or anyone else may have been given too much Dantrium Injection. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Keep the telephone numbers for these services handy. Have the Dantrium Injection pack or the information here available to give details if needed.

After being treated with Dantrium

Things you must do

You must tell your doctor if:

  • You are pregnant;
  • You are taking any medicines including medicines that you buy without a prescription from a pharmacy, supermarket or health food shop. In particular, tell your doctor if you are taking any heart medicines or tranquillisers (medicines to reduce anxiety or help you sleep).

Things you must not do

For 2 days after treatment, do not operate machinery or do anything else that could be dangerous when not fully alert. Weakness, dizziness and drowsiness can continue for up to 48 hours after treatment.

Things to be careful of

Take care when getting out of bed or walking downstairs. You may experience lightheadedness, leg weakness or loss in grip strength after treatment with Dantrium.

Be careful when eating or drinking on the day you have been treated with Dantrium. Some people have difficulty swallowing after treatment with Dantrium. Choking has been reported.

Storage and disposal

Storage

Dantrium will normally be stored in a hospital. It should be stored below 25 degrees C and should be protected from light (kept in the packaging before use).

Disposal

Used or damaged vials should be disposed of by incineration.

Schedule of Dantrium

Dantrium is a prescription only medicine (Schedule 4).

Side effects of Dantrium

Tell your doctor as soon as possible if you have any concerns about being treated with Dantrium for injection. All medicines can have side effects. You may need medical treatment if you get some of the side effects.

After treatment with Dantrium, tell your doctor if you notice:

  • Swelling or tenderness around a vein;
  • Itchy skin rash or reddening of the skin;
  • Breathlessness;
  • Drowsiness or dizziness;
  • Weakness in the legs or loss of grip strength;
  • Confusion;
  • Nausea;
  • Loss of appetite;
  • Diarrhoea;
  • Jaundice;
  • Swollen abdomen;
  • Easy bleeding.

Tell your doctor if you notice any other side effect after treatment with Dantrium, even if it is not on this list.

For further information talk to your doctor.

References

  1. Dantrium Powder for Injection Consumer Medicine Information (CMI).  West Ryde, NSW: Pfizer Australia Pty Ltd. November 2010. [PDF]
  2. Dantrium Powder for Injection Product Information (PI). West Ryde, NSW: Pfizer Australia Pty Ltd. September 2010. [PDF]
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Dates

Posted On: 22 July, 2003
Modified On: 3 December, 2018
Reviewed On: 3 December, 2018

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Created by: myVMC