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Creon 5000/10000 & Forte

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Generic Name: Pancrelipase
Product Name: Creon 5000/10000 & Forte


Used to replace pancreatic enzymes in patients who have insufficient amounts due to a number of reasons:
– cystic fibrosis
– chronic pancreatitis
– after having pancreas removed
– gastrointestinal bypass surgery
– obstruction of the pancreatic duct.


The body requires enzymes released by the pancreas in order to properly digest foods. Creon 5000, Creon 10000 and Creon Forte replace these enzymes in the duodenum, the place they would usually be released, and normal digestion can take place. Proper digestion is important to ensure the body receives all the nutrients contained in food.

Dose advice

Due to the nature of the diseases that may result in pancreatic enzyme deficiency, each patient is different and doses must be titrated individually. Some guidelines:
Adults, elderly and children (excluding CF)
– initially one Creon 5000, Creon 10000 or Creon Forte with each meal
– add doses slowly and with adequate hydration (100ml water with each dose)
– regular review and ultrasound should be performed on all patients requiring increasing doses
Infants and children with CF
– lipase 1500 to 6000 BP units/kg/meal
– maximum recommended dose of lipase is 20000 BP units/kg/day


Creon 5000, Creon 10000: Unscheduled
Creon Forte: S4

Common side effects

– nausea
– vomiting
– abdominal pain

Uncommon side effects

– diarrhoea
– abnormal stools
– constipation
– allergic or hypersensitivity reaction of the skin


For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 22 July, 2003

Created by: myVMC