Cefkor CD

Generic Name: Cefaclor monohydrate
Product Name: Cefkor CD

Indication

Used in the treatment of infectious in adults (and children > 12 years) caused by pathogens susceptible to Cofactor. Including:

• Lower respiratory infections (e.g. community acquired pneumonia, acute bronchitis and exacerbations of chronic bronchitis)
• Upper respiratory tract infections (e.g. pharyngitis, tonsillitis, acute bacterial sinusitis)
• Lower urinary tract infections
• Skin and connective tissue structure infections.

Action

Microbiology

• Cefaclor is a cephalosporin antibiotic with bactericidal activity. It is active against a variety of bacteria responsible for common infections, including some bacteria that are resistant to penicillin and other cephalosporin antibiotics.

Pharmacokinetics

• Cefkor is well absorbed from the gut and peak plasma levels are achieved in close to 2 hours. When taken with food, the time taken to peak plasma levels increases, though the degree of absorption also increases.
• Cefaclor is not metabolised.
• Plasma half live in healthy patients is about 50 minutes.

Dose advice

Adults

Standard dosage: 375 mg. Twice daily.

Pneumonia, acute bacterial sinusitis: 750 mg, twice daily.

Renal impairment: Administer with caution in patients with severe renal impairment, though dosage adjustments are not usually required.

Use in pregnancy: (Category B1) Safety has not been established. Avoid the use of Cefkor in women of childbearing potential unless its use is considered essential.

Use in lactation: Small amounts of cefaclor are excreted in breast milk. Use with caution in breastfeeding women.

Children

Safety and efficacy have not been studied.

Schedule

S4

Common side effects

• Diarrhoea
• Nausea
• Vomiting
• Rash
• Itch
• Headache
• Vaginal moniliasis.

Uncommon side effects

As above

For further information talk to your doctor.