Generic Name: Diltiazem hydrochloride
Product Name: Cardizem CD
-Mild to moderate essential hypertension
-Chronic stable angina
-Diltiazem is a slow calcium channel blocker.
-It inhibits the influx of calcium ions during membrane depolarisation of cardiac and vascular smooth muscle.
-Reduction in blood pressure is mediated by relaxation of vascular smooth muscle and resultant decrease in peripheral vascular resistance.
-Hypertension: Initial dose is 180-240 mg once daily. Maximum effect usually seen by 14 days of therapy. Dosage can be thus adjusted every 2 weeks. Maintenance dose is 240-360 mg/day.
-Angina: Initial dose is 180 mg daily and maximum is 360 mg daily. Dose should be titrated over 7-14 days.
Common side effects
-First degree atrioventricular block
Uncommon side effects
-Cardiovascular – angina, arrythmia, atrioventricular block, bundle branch block, congestive heart failure, hypotension, syncope, tachycardia
-Nervous system â?? depression, somnolence, insomnia, tinnitus, tremor, nervousness, paraethesia, dream abnormalities, amnesia, hallucinations and gait abnormalities
-Gastrointestinal â?? anorexia, constipation, diarrhoea, dry mouth, dyspepsia, vomiting, thirst, weight increase, mild elevations of liver function tests
-Dermatological â?? petechiae, photosensitivity, pruritus, urticaria
-Others â?? amblyopia, dyspnoea, epistaxis, hyperglycaemia, hyperuricaemia, impotence, eye irritation, nocturia, polyuria, creatine kinase increase
For further information talk to your doctor.