Generic Name: ciprofloxacin (as hydrochloride)
Product Name: C-Flox
Indication: What C-Flox is used for
C-Flox tablets are used to treat certain infections of the lungs, skin, bones and joints, kidney and bladder, prostate, bowel.
C-Flox is also used to treat inhalational anthrax (an infection caused by breathing in the spores of bacteria).
Ask your doctor if you have any questions about why C-Flox has been prescribed for you. Your doctor may have prescribed C-Flox for another reason.
Action: How C-Flox works
C-Flox tablets contain the active ingredient ciprofloxacin (as hydrochloride), which is an antibiotic belonging to a group of medicines called quinolones. These antibiotics work by killing the bacteria that are causing your infection.
C-Flox does not work against infections caused by viruses, such as colds or the flu.
The active ingredient in C-Flox is ciprofloxacin (as hydrochloride). C-Flox 250 contains 250 mg of the active ingredient ciprofloxacin (as hydrochloride). C-Flox 500 contains 500 mg of the active ingredient ciprofloxacin (as hydrochloride). C-Flox 750 contains 750 mg of the active ingredient ciprofloxacin (as hydrochloride).
The tablets also contain the inactive ingredients microcrystalline cellulose, maize starch, crospovidone, pregelatinised maize starch, colloidal anhydrous silica, magnesium stearate, hypromellose, titanium dioxide CI77891 (E171), polydextrose, triacetin, macrogol 8000.
The tablets are gluten free.
Dose advice: How to use C-Flox
Before you take C-Flox
When you must not take it
Do not take C-Flox if you have an allergy to:
- Other quinolone antibiotics including nalidixic acid, moxifloxacin, norfloxacin;
- Any of the ingredients listed here.
Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing; wheezing or shortness of breath.
Do not take C-Flox if you are already taking a medicine called tizanidine, a muscle relaxant used to treat spasticity associated with multiple sclerosis, injury or diseases of the spinal cord. C-Flox can interfere with tizanidine and can lead to undesirable side effects.
Do not take C-Flox tablets after the expiry date (EXP) printed on the pack has passed. If you take this medicine after the expiry date, it may not work as well.
Do not take C-Flox if the packaging is torn, shows sign of tampering or the tablets do not look quite right.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether this medicine is safe to use in pregnant women. Ciprofloxacin and other similar medicines have caused joint disease in immature animals. Your doctor will discuss the risks and benefits of taking C-Flox during pregnancy.
Do not take C-Flox if you are breastfeeding. C-Flox passes into breast milk and may affect your baby. Your doctor will tell you whether you should take it or temporarily stop breastfeeding while you are taking the tablets.
Do not give C-Flox to children and growing adolescents unless you are told by your doctor to do so. C-Flox is not recommended for children under 18 years of age except for use in inhalational anthrax.
C-Flox should be used with caution in elderly patients as they are more prone to side effects.
Tell your doctor if you have or have had any medical conditions, especially the following:
- Epilepsy, fits, seizures or convulsions;
- Kidney disease;
- Liver disease;
- Arrhythmias (fast or irregular heartbeats). C-Flox may increase the risk of arrhythmias, especially in the elderly or patients with low potassium levels;
- Conditions where you have taken corticosteroids. You may be at increased risk of swelling of the tendons. Symptoms include pain, tenderness and sometimes restricted movement
- Myasthenia gravis, a condition where the muscles become weak. C-Flox can worsen symptoms of this condition;
- A history of tendon disorders with the use of quinolones (e.g. moxifloxacin, norfloxacin, nalidixic acid).
If you have not told your doctor about any of the above, tell them before you start taking C-Flox.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines may be affected by C-Flox, or may affect how well it works. These include:
- Medicines used to treat arrhythmias (fast or irregular heartbeats);
- Theophylline, a medicine used to treat asthma;
- Oral anticoagulants, medicines used to prevent blood clots such as warfarin;
- Phenytoin, a medicine used to treat epilepsy;
- Medicines used to control diabetes;
- Didanosine, a medicine used to treat viral infections;
- Ciclosporin, a medicine used in organ transplantation or to treat certain problems with the immune system;
- NSAIDs (non-steroidal anti-inflammatory drugs), medicines used to treat pain, arthritis and other inflammatory conditions;
- Methotrexate, a medicine used to treat arthritis, severe psoriasis or some types of cancer;
- Duloxetine, a medicine used to treat depression, anxiety and nerve pain in people with diabetes;
- Clozapine, a medicine used to treat schizophrenia;
- Ropinirole, a medicine used to treat Parkinson’s disease or restless legs syndrome;
- Lidocaine, a local anaesthetic used to numb pain or cause loss of sensation;
- Oxpentifylline, a medicine used to treat circulation disorders;
- Sildenafil, a medicine used to treat erectile dysfunction;
- Agomelatine, a medicine used to treat depression;
- Zolpidem, a medicine used to treat sleep disorders.
Some medicines may interfere with the absorption of C-Flox.
- Multivitamins, mineral supplements, antacids (used for indigestion) and other medicines containing iron, zinc, magnesium, aluminium or calcium;
- Sucralfate, a medicine used to treat duodenal or stomach ulcers;
- Medicines used to treat HIV infection;
- Probenecid, a medicine used to treat gout;
- Omeprazole, a medicine used to treat stomach ulcers and other conditions where the stomach produces too much acid;
- Sevelamer, a medicine used to treat high blood levels of phosphorus in patients with kidney disease who are on dialysis;
- Metoclopramide, a medicine used to treat nausea and vomiting, heartburn and stomach pain.
You can still take these medicines while you are taking C-Flox. However, you must take C-Flox at least 2 hours before or 2 hours after taking any of these medicines.
If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking C-Flox.
How to take C-Flox
Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained here.
If you do not understand the instructions printed on the pack, ask your doctor or pharmacist for help.
How much to take
Your doctor will tell you how much and how often you should take C-Flox. This will depend on the type of infection and any medical conditions you have.
The usual adult dosage for most infections is one tablet twice daily for 7 to 14 days. You may need to take your tablets for a longer period of time for some types of infection.
Elderly people and people with kidney problems may need smaller doses.
How to take it
Swallow the tablets whole with a glass of water.
When to take it
C-Flox tablets are usually taken twice a day.
Take your tablets at the same time each day, preferably on an empty stomach. However, C-Flox can be taken with or without food.
How long to take it for
Continue taking C-Flox until you have finished the pack or for as long as your doctor tells you.
The length of treatment may vary from one to 28 days or longer depending on the type of infection.
Do not stop taking C-Flox even if you are feeling better unless advised by your doctor. If you stop taking C-Flox too soon, the infection may not clear completely or your symptoms may return.
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
Otherwise, take it as soon as you remember, and then go back to taking your tablets as you would normally.
Do not take a double dose to make up for the dose you missed.
If you are not sure what to do or have any questions, ask your doctor or pharmacist for help.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
If you take too much (overdose)
Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26), or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much C-Flox. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
While you are taking C-Flox
Things you must do
Before starting any new medicine, tell your doctor or pharmacist that you are taking C-Flox.
Tell all the doctors, dentists and pharmacists who are treating you that you are taking C-Flox.
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking this medicine.
If you are about to have any laboratory, blood or urine tests, tell your doctor that you are taking this medicine. It may affect the results of some tests.
Drink plenty of water while you’re taking C-Flox. This helps to stop crystals forming in the urine.
If you become pregnant while taking C-Flox, tell your doctor immediately.
If you develop diarrhoea, tell your doctor or pharmacist immediately. Do this even if it occurs several weeks after you have stopped taking C-Flox. Diarrhoea may mean that you have a serious condition affecting your bowel. You may need urgent medical care. Do not take any medicines for diarrhoea without checking with your doctor or pharmacist.
Tell your doctor immediately if you experience symptoms of depression or self-endangering behaviour. C-Flox should be discontinued immediately.
Things you must not do
Do not use C-Flox to treat any other conditions unless your doctor tells you to.
Do not give your medicine to anyone else, even if they have the same condition as you.
Do not stop taking your tablets because you are feeling better unless your doctor told you to do so. If you do not complete the full course prescribed by your doctor, some of the bacteria causing your infection may not be killed. These bacteria may continue to grow and multiply so that your infection may not clear up completely or it may return.
Things to be careful of
Avoid excessive exposure to direct sunlight. Your skin may become more prone to sunburn. If such a reaction occurs, stop taking C-Flox immediately and tell your doctor.
Be careful driving or operating machinery until you know how C-Flox affects you. C-Flox may cause dizziness in some people, especially after the first few doses. Your ability to drive and/or operate machinery may be impaired. If you drink alcohol while taking this medicine, dizziness may be worse.
C-Flox tablets may increase the stimulatory effects of caffeine.
After taking C-Flox
Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the pack they may not keep well.
Keep your tablets in a cool dry place where the temperature stays below 25°C. Do not store C-Flox or any other medicine in the bathroom or near a sink. Do not leave C-Flox in the car or on window sills. Heat and dampness can destroy some medicines.
Keep C-Flox where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor tells you to stop taking C-Flox, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.
Schedule of C-Flox
C-Flox is an S4 (prescription only) medicine.
Side effects of C-Flox
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking C-Flox. This medicine is generally well tolerated and helps most people their bacterial infections, but it may have unwanted side effects in some people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need to stop taking the tablets or have medical treatment if you get some of these side effects.
Do not be alarmed by this list of possible side effects. You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
These are the more mild and common side effects of ciprofloxacin.
Tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital if you notice any of the following:
- Severe skin rashes, peeling of the skin and/or mucosal reactions;
- Signs of allergy such as rash, swelling of the face, lips mouth, throat or other parts of the body, shortness of breath, wheezing or trouble breathing;
- Yellowing of the skin and eyes, also called jaundice;
- Severe watery or bloody diarrhoea, even if it occurs several weeks after taking your tablets;
- Fits (seizures, convulsions)
- Confusion, nightmares, hallucinations, and psychotic reaction (even progressing to self-endangering behaviour);
- Fast or irregular heartbeats;
- Visual disturbances;
- Ringing in the ear, loss of hearing;
- Abdominal pain/cramps. Very rarely this can progress to a serious condition accompanied by fever and fatigue;
- Pain, burning, tingling, numbness and/or weakness in your limbs.
The above list includes serious side effects that may require medical attention.
Photosensitivity (getting sunburnt very easily) can occasionally occur with C-Flox. However, it is temporary and staying out of direct sunlight while on C-Flox will prevent it from happening.
Rarely, there can be a worsening of the symptoms of myasthenia gravis. This is a condition in which muscles become weak and tire easily, causing drooping eyelids, double vision, difficulty in speaking and swallowing, and sometimes muscle weakness in the arms or legs.
Rarely, the Achilles tendon (extending from the calf to the heel of the foot) or other tendons have been torn after C-Flox therapy. Tell your doctor immediately if you feel any discomfort, pain or inflammation of a tendon.
Rarely, you may experience hyperglycaemia (high blood sugar), or hypoglycaemia (low blood sugar). Symptoms of hyperglycaemia include increased thirst, appetite and urination. Symptoms of hypoglycaemia include weakness, shaking, sweating, lightheadedness, headache, behavioural changes, confusion, numbness/pins and needles in the lips, fingers or toes, irritability and hunger. Tell your doctor if you experience these symptoms.
If you experience any of these symptoms during treatment with C-Flox tablets, tell your doctor immediately. C-Flox may need to be discontinued.
Tell your doctor if you notice anything that is making you feel unwell. Other side effects not listed above may also occur in some people.
For further information talk to your doctor.